VEGF、脂肪因子与结直肠癌发病相关机制的研究进展

Research Progress of VEGF, Adipokine and the Pathogenesis of Colorectal Cancer

结直肠癌作为一种新发病例及死亡病例均在全世界排名前列的癌症,其发病机制尚需深入研究。血管内皮细胞生长因子能促进新生血管的生成,在肿瘤增殖、侵袭和迁移过程中起到重要作用。脂肪因子包括瘦素、脂联素、网膜素、细胞因子等,这些脂肪因子与结直肠癌的发生发展密切相关。本文就结直肠癌发生发展进程与血管内皮细胞生长因子及脂肪因子之间的关系及血管内皮细胞生长与脂肪因子之间的联系进行综述,期望为防治结直肠癌提供积极的理论依据。

Colorectal cancer is a cancer with a high incidence of new cases and deaths in the world, and its pathogenesis needs to be further studied. Vascular endothelial cell growth factor can promote the formation of new blood vessels and play an important role in the process of tumor proliferation, invasion and migration. Adipokines include leptin, adiponectin, retinin and cytokines, and these adipokines are closely related to the occurrence and development of colorectal cancer. This paper reviews the relationship between the occurrence and development of colorectal cancer and vascular endothelial cell growth factor and adipokine as well as the relationship between vascular endothelial cell growth factor and adipokine, hoping to provide a positive theoretical basis for the prevention and treatment of colorectal cancer.