TRAF7在肿瘤发展中的作用

The Role of TRAF7 in Tumorigenesis

肿瘤坏死因子受体(TNF-R)相关因子(TRAF)家族有七个成员,是TNF-R超家族受体的细胞质区域偶联的信号转导分子。TRAF蛋白主要作为支架或酶蛋白激活NF-κB、MAPK等不同的下游信号通路,参与胚胎发育、组织稳态以及先天性和适应性免疫反应调节等重要生理过程。TRAF7是近年来被发现的一种具有E3泛素连接酶活性的TRAF家族成员,含有一个N端RING指结构域和一个负责底物识别的C端WD40结构域。最近几年的研究发现,TRAF7是一种新的肿瘤抑制蛋白,与人类多种癌症的发生和发展有着密切联系。本文主要综述了TRAF7与脑膜瘤、间皮瘤以及肝癌等几种人类肿瘤的发生和发展过程中的作用,期望对于认识肿瘤发病机制和治疗靶标有帮助。

Abstract: The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family has seven members and is characterized as signaling transduction molecules coupled to the cytoplasmic regions of the TNF-R superfamily. All the TRAFs proteins functionally act as a scaffold and/or enzymatic proteins to regulate activation of mitogen-activated protein kinases (MAPKs) and transcription factors of nuclear factor-κB family (NF-κB). All TRAFs have been identified to be widely involved in embryonic development, tissue homeostasis, and regulation of innate and adaptive immune responses. TRAF7, as the last discovered member of the TRAFs protein with E3 ligase activation, containing an N-terminal RING finger domain and a C-terminal WD40 domain, has been identified to be involved in the genesis and progression of several human cancers, suggesting TRAF7 as a novel tumor suppressor protein. The paper attempts to review the role of TRAF7 in the genesis and progression of Meningioma, Mesothelioma and Hepatocellular Carcinoma, hoping to be helpful for understanding tumor pathogenesis and therapeutic targets.