肾母细胞瘤的预后危险因素研究进展

Research Advances of Prognostic Risk Factors of Wilms Tumor

肾母细胞瘤(Wilms tumor)是小儿最常见的肾脏恶性肿瘤,经常需要手术与放化疗结合的系统性综合治疗。随着目前医学技术的进展,肾母细胞瘤患儿的远期预后有了极大的改善,但仍存在某些特性类型的肾母细胞瘤患儿具有较差的预后,且对化疗以及放射性治疗反应性不佳。因此,利用临床上的预后危险因素对预后不佳的患儿进行早期识别显得十分重要。本文通过对国内外的肾母细胞瘤研究文献进行总结和归纳,对目前主要的肾母细胞瘤预后危险因素作一综述。

Wilms tumor is the most common renal malignant tumor in children and it often needs systematic comprehensive treatment of surgery combined with radiotherapy and chemotherapy. Thanks to recent advances in medicine technology, the long-term prognosis of Wilms tumor patients has been greatly improved, but there are still certain types of Wilms tumor, whose response to chemotherapy and/or radiotherapy is not effective, and those patients have a relatively poorer prognosis. Therefore, it is of great importance to identify poor-prognosis patients using clinical risk factors in early stage. This article reviews the current prognostic risk factors by summarizing research articles on Wilms tumor at home and abroad.