P-糖蛋白在肿瘤中的研究新进展

New Research Progress of P-Glycoprotein in Tumor

P-糖蛋白是一种位于细胞膜上,对疏水性及两性化合物具有特异性的一类转运蛋白。在生理条件下,P-糖蛋白分布在机体内多种组织、器官中,在药物的吸收、分布、代谢及排泄过程中都发挥着重要的作用。P-糖蛋白广泛存在于各种肿瘤细胞,与其发展密切相关。P-糖蛋白可加速机体抗癌药物产生耐药,调控P-糖蛋白水平可以调控肿瘤的发展和减少肿瘤药物耐药性。

P-glycoprotein is a kind of transporter which is located on the cell membrane and has specificity for hydrophobic and amphoteric compounds. Under physiological conditions, P-glycoprotein is distributed in various tissues and organs in the body, and plays an important role in the absorption, distribution, metabolism and excretion of drugs. P-glycoprotein exists widely in various tumor cells and is closely related to its development. P-glycoprotein can accelerate anti-cancer drug resistance in the body, and regulate P-glycoprotein level which can regulate tumor development and reduce drug resistance.