宫颈高级别上皮内瘤变的筛查与治疗研究进展

Research Progress in Screening and Treatment of High-Grade Intraepithelial Neoplasia of Cervix

宫颈癌(CC)是女性第四大恶性肿瘤,是最常见的女性生殖系统恶性肿瘤,每年预估有530,000例新发病例和270,000例死亡病例。子宫颈高级别鳞状上皮内病变(HSIL)是CC的癌前病变,包括宫颈上皮内瘤变Ⅱ级(CIN2)、宫颈上皮内瘤变Ⅲ级(CIN3)。CC是唯一一种可以预防的恶性肿瘤,对HSIL的筛查以及规范治疗是减少浸润性子宫颈癌的重点内容。本研究通过对HSIL的筛查和治疗手段进行综述,以提高对HSIL的认识,推进HSIL防治工作,降低宫颈癌前病变以及CC的发病率。

Cervical cancer (CC) is the fourth largest malignancy in women and the most common malignancy of the female reproductive system, with an estimated 530,000 new cases and 270,000 deaths annually. High-grade squamous intraepithelial lesions (HSIL) are precancerous lesions of CC, including cervical intraepithelial neoplasia grade Ⅱ (CIN2) and cervical intraepithelial neoplasia grade Ⅲ (CIN3). CC is the only malignant tumor that can be prevented. Screening and standard treatment of HSIL is the key to reduce invasive cervical cancer. In this study, the screening and treatment methods of HSIL were reviewed to improve the understanding of HSIL, promote the prevention and treatment of HSIL, and reduce the incidence of cervical precancerous lesions and CC.