2型糖尿病与结直肠腺瘤关系研究进展

Research Progress on the Relationship between Type 2 Diabetes Mellitus and Colorectal Adenomas

多数结直肠癌(Colorectal Cancer, CRC)是从结直肠腺瘤(Colorectal Adenomas, CRA)演变而来的。目前主要通过早期发现和切除结直肠腺瘤来预防结直肠癌的发生。2型糖尿病(Type 2 Diabetes Mellitus, T2DM)作为一种代谢性疾病,与多种癌症密切相关,包括结直肠癌。近年来,有研究显示2型糖尿病也是结直肠腺瘤的独立危险因素,其中潜在机制尚不明确。本文主要从2型糖尿病与结直肠腺瘤相关性、糖尿病人群中影响结直肠腺瘤发生的影响因素、两者可能的潜在机制进行综述,以提高对临床早期筛查高风险人群的重视。

The majority of colorectal cancer cases are attributed to the presence of colorectal adenomas. Currently, the primary approach for preventing colorectal adenomas is through early detection and removal. Type 2 diabetes mellitus, as a metabolic disorder, exhibits a robust association with various cancers, including colorectal cancer. Recent studies consistently demonstrate that type 2 diabetes mellitus independently increases the risk of developing colorectal adenomas;however, the precise underlying mechanisms remain incompletely elucidated. This paper aims to explore the correlation between type 2 diabetes mellitus and colorectal adenomas, identify factors influencing their development in individuals with diabetes, and shed light on potential underlying mechanisms. The findings underscore the significance of early clinical screening among high-risk groups.