宫颈端粒酶hTERC基因的表达和宫颈高危型HPV感染的型别的相关研究

Research on Expression of Telomerase hTERC Gene and Infection of High Risk HPV in Cervix

宫颈癌是妇产科常见的恶性肿瘤之一,在宫颈癌的发生过程中,高危型人乳头瘤病毒(human papillomavirus, HPV)感染是重要的致瘤因素,HPV病毒有多个型别,常见为HPV16、18型感染。近几年的研究表明,宫颈癌的发生发展与人类染色体端粒酶基因扩增有联系。本文就端粒酶基因扩增和宫颈HPV感染的型别的相关研究进行综述。

Cervical cancer is one of the commonest malignant tumors in obstetrics and gynecology. In the development of cervical cancer, the infection of high risk human papillomavirus (HPV) is an im-portant tumorigenic factor, common for HPV16 and HPV18. Research in recent years shows that the occurrence and development of cervical cancer is related to the human chromosome telomerase gene amplification. In this paper, the correlation between telomerase gene amplification and cervical HPV infection is reviewed.