摘要
目的:观察高危复发肺癌术后化疗后,予胸腺肽α1维持治疗,对无病生存期的影响。方法:选取我科2011~2012年有高危复发风险的肺癌术后病人,分成两组,一组化疗后予胸腺肽α1 1.6 mg BIW维持治疗>6月,一组化疗后未行胸腺肽α1维持治疗的病人,比较两组无病生存期。结果:予胸腺肽α1维持治疗组的无病生存期较未行免疫维持治疗组稍延长,但P = 0.385,差异无统计学意义。如果排除脑转移后,予胸腺肽α1组无病生存期明显延长,P = 0.039。结论:建议肺癌术后,高危复发病人,常规辅助化疗后,常规予胸腺肽α1维持治疗。
Objective: To investigate the clinical benefit of immunization maintenance treatment with Tα1 on postoperative lung cancer with high risk recurrence. Methods: Patients of postoperative lung cancer with high risk recurrence were chosen between 2011-2012 and divided into two groups: Tα1 maintenance treatment group after chemotherapy, not with Tα1 maintenance treatment group after chemotherapy. Tα1 is used twice a week at least 6 months Median time to disease progression (TTP) were analyzed by Kaplan-Meier method. Results: The Tα1 group prolong TTP, but P = 0.385. IF brain metastases are rejected. The Tα1 group prolongs TTP obviously, P = 0.039. Conclusion: Immunization maintenance treatment with Tα1 is recommended for lung cancer with high risk recurrence.
出处
《亚洲肿瘤科病例研究》
2018年第4期68-72,共5页
Asian Case Reports in Oncology