反应型铜离子荧光探针的研究进展

Review on the Development of Reaction-Based Fluorescent Sensor for Copper Ion

铜离子在生命体内发挥重要作用,其含量异常与多种疾病关系密切。对生命体内铜离子进行原位实时检测具有重要意义。荧光成像作为一种非侵入性的新型检测方法,具有高灵敏度、高选择性、响应快速等优点,在生物医学领域有重要应用。本文按照探针响应铜离子的不同反应机理进行分类,对近五年报导的反应型铜离子荧光探针进行了综述,以期铜离子荧光探针能收获更多重要成果。

Copper ion plays important roles in living system, whose abnormality relates closely with many diseases. Thus it’s meaningful to detect changes of copper ion in living systems in situ and in re-al-time. Fluorescent imaging is gaining great development in life science, which is characterized as non-invasive, high sensitivity and specificity, short response-time. We summarized the reac-tion-based fluorescent sensors for copper ion reported within the past five years, with the hope of more important works about fluorescent sensors for copper ion in the near future.