摘要
Here, we present a longitudinal analysis of two patients who recovered from COVID-19 more than 8 months prior but showed persistent serological detection of anti-SARS-CoV-2 IgM. We still do not know the exact reason for this prolonged persistence of IgM in these patients. To our knowledge, these are the first reports of IgM persistence in the context of SARS-CoV-2 infection and point to the need for no longer using IgM as a diagnostic criterion for acute or recent COVID-19. One should opt for gold standard molecular methodologies due to their high sensitivity and specificity.
Here, we present a longitudinal analysis of two patients who recovered from COVID-19 more than 8 months prior but showed persistent serological detection of anti-SARS-CoV-2 IgM. We still do not know the exact reason for this prolonged persistence of IgM in these patients. To our knowledge, these are the first reports of IgM persistence in the context of SARS-CoV-2 infection and point to the need for no longer using IgM as a diagnostic criterion for acute or recent COVID-19. One should opt for gold standard molecular methodologies due to their high sensitivity and specificity.
作者
Carlos David A. Bichara
Ednelza S. G. Amoras
Gergiane L. Vaz
Cléa N. C. Bichara
Isabella P. C. Amaral Amaral
Antonio C. R. Vallinoto
Carlos David A. Bichara;Ednelza S. G. Amoras;Gergiane L. Vaz;Cléa N. C. Bichara;Isabella P. C. Amaral Amaral;Antonio C. R. Vallinoto(Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará (UFPA), Belém, Brasil;Amaral Costa Medicina Diagnóstica, Belém, Brasil;Faculdade de Medicina, Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará (UEPA), Belém, Brasil;Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Instituto de Ciências Biológicas, Universidade Federal do Pará (UFPA), Belém, Brasil)
