摘要
<strong>Aim: </strong>This study is aimed at determining the total PSA (tPSA), free PSA (fPSA) concentrations and free to total PSA ratio (f/tPSA) and their utility in prostate cancer (PCa) risk stratification among male lepromatous leprosy patients in Edo state, Nigeria. <strong>Methods:</strong> Forty participants and thirty controls participated in this study. A structured questionnaire was administered to each participant to elicit details such as their personal data, age, sex, residence, medications, alcohol consumption, smoking habit, length of time of diagnosis, sexual activities, as well as the history of any other underlying diseases. Blood samples were collected from the participants. Total and free PSA concentrations in the samples were measured using ELISA method. <strong>Results:</strong> Significantly (p = 0.042) higher serum fPSA among the leprosy patients (0.22 ± 0.12 ng/ml) compared with the healthy controls (0.17 ± 0.09 ng/ml). There were no significant (p = 0.055) difference in the mean tPSA between the leprosy patients (2.69 ± 2.25 ng/ml) compared with the control (1.95 ± 0.69 ng/ml). Similarly, no significant (p = 0.548) difference was observed in PSA ratio between the control (0.08 ± 0.04) and the leprosy patients (0.09 ± 0.03). <strong>Conclusion:</strong> Our study indicated no significant differences in tPSA and f/tPSA between the leprosy patients and their healthy control. Elevated tPSA as well as f/tPSA levels that fell within the high risk zones of PCa were more prevalent among patients aged ≥ 70 years, not married, who rarely had sexual intercourse and those with longer disease duration.
<strong>Aim: </strong>This study is aimed at determining the total PSA (tPSA), free PSA (fPSA) concentrations and free to total PSA ratio (f/tPSA) and their utility in prostate cancer (PCa) risk stratification among male lepromatous leprosy patients in Edo state, Nigeria. <strong>Methods:</strong> Forty participants and thirty controls participated in this study. A structured questionnaire was administered to each participant to elicit details such as their personal data, age, sex, residence, medications, alcohol consumption, smoking habit, length of time of diagnosis, sexual activities, as well as the history of any other underlying diseases. Blood samples were collected from the participants. Total and free PSA concentrations in the samples were measured using ELISA method. <strong>Results:</strong> Significantly (p = 0.042) higher serum fPSA among the leprosy patients (0.22 ± 0.12 ng/ml) compared with the healthy controls (0.17 ± 0.09 ng/ml). There were no significant (p = 0.055) difference in the mean tPSA between the leprosy patients (2.69 ± 2.25 ng/ml) compared with the control (1.95 ± 0.69 ng/ml). Similarly, no significant (p = 0.548) difference was observed in PSA ratio between the control (0.08 ± 0.04) and the leprosy patients (0.09 ± 0.03). <strong>Conclusion:</strong> Our study indicated no significant differences in tPSA and f/tPSA between the leprosy patients and their healthy control. Elevated tPSA as well as f/tPSA levels that fell within the high risk zones of PCa were more prevalent among patients aged ≥ 70 years, not married, who rarely had sexual intercourse and those with longer disease duration.
作者
Babatunde Ishola Gabriel Adejumo
David Osebhor
Uchechukwu Dimkpa
Usman Itakure Abdulkadir
Oladimeji Nasiru Abdulrahman
Uzor Simon
Kelechi Ncheta Nkwazema
Noreen Ebelechukwu Agbapuonwu
Grace Umahi-Ottah
Babatunde Ishola Gabriel Adejumo;David Osebhor;Uchechukwu Dimkpa;Usman Itakure Abdulkadir;Oladimeji Nasiru Abdulrahman;Uzor Simon;Kelechi Ncheta Nkwazema;Noreen Ebelechukwu Agbapuonwu;Grace Umahi-Ottah(Medical Laboratory Science Department, University of Benin, Benin City, Nigeria;Physiology Department, Nnewi Campus, Nnamdi Azikiwe University, Awka, Nigeria;Department of Medical Laboratory Science, College of Health Sciences and Technology, Markafi, Kaduna State, Nigeria;Department of Medical Laboratory Science, College of Health Technology, Offa, Kwara State;Department of Applied Science, Faculty of Health and Applied Sciences, University of West of England, Bristol, UK;Medical Laboratory Science Department, National Ear Care Centre, Kaduna, Kaduna State, Nigeria;Department of Nursing, Nnamdi Azikwe University, Akwa, Nigeria;Department of Physiology, Ebonyi State University, Abakaliki, Nigeria)
