摘要
<strong>Background: </strong>The alteration of lymphocyte subpopulations can help to predict the severity and the prognosis of severe Coronavirus disease 2019 (COVID-19). Our goal was to describe the kinetics of lymphocyte subsets, and their impact on the severity and mortality in critically ill COVID-19 patients. <strong>Methods: </strong>We collected demographic data, comorbidities, clinical signs on admission, laboratory findings on admission then a follow-up during hospitalization. Lymphocyte subsets including CD3+ T cells, CD4+ T cells, CD8+ T cells, B cells, and natural killer (NK) cells were counted by flow cytometer. <strong>Results:</strong> On admission, we observed lymphopenia in 57% of cases, decreased CD3+ T cells in 76% of cases, decreased CD4+ T cells in 81% of cases, decreased CD8+ T cells in 62% of cases, decreased B cells in 52% of cases, and decreased natural killer (NK) cells in 33% of cases. After treatment, decreased CD3+ T cells, decreased CD4+ T cells, decreased CD8+ T cells, and decreased natural killer cells were predictor factors of mortality, in the univariable analysis.<strong> Conclusion:</strong> CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were predictor factors of severity, ICU mortality, and also a useful tool for predicting disease progression.
<strong>Background: </strong>The alteration of lymphocyte subpopulations can help to predict the severity and the prognosis of severe Coronavirus disease 2019 (COVID-19). Our goal was to describe the kinetics of lymphocyte subsets, and their impact on the severity and mortality in critically ill COVID-19 patients. <strong>Methods: </strong>We collected demographic data, comorbidities, clinical signs on admission, laboratory findings on admission then a follow-up during hospitalization. Lymphocyte subsets including CD3+ T cells, CD4+ T cells, CD8+ T cells, B cells, and natural killer (NK) cells were counted by flow cytometer. <strong>Results:</strong> On admission, we observed lymphopenia in 57% of cases, decreased CD3+ T cells in 76% of cases, decreased CD4+ T cells in 81% of cases, decreased CD8+ T cells in 62% of cases, decreased B cells in 52% of cases, and decreased natural killer (NK) cells in 33% of cases. After treatment, decreased CD3+ T cells, decreased CD4+ T cells, decreased CD8+ T cells, and decreased natural killer cells were predictor factors of mortality, in the univariable analysis.<strong> Conclusion:</strong> CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were predictor factors of severity, ICU mortality, and also a useful tool for predicting disease progression.
作者
Amra Ziadi
Abdelhamid Hachimi
Raja Hazime
Imane Brahim
Brahim Admou
Fouzia Douirek
Ahmed R. El Adib
Said Younous
Abdenasser M. Samkaoui
Amra Ziadi;Abdelhamid Hachimi;Raja Hazime;Imane Brahim;Brahim Admou;Fouzia Douirek;Ahmed R. El Adib;Said Younous;Abdenasser M. Samkaoui(Polyvalent Intensive Care Unit, Arrazi Hospital, Mohammed VI<sup>th</sup> University Centre, Cadi Ayyad University, Marrakech, Morocco;Medical Intensive Care Unit, Arrazi Hospital, Mohammed VI<sup>th</sup> University Centre, Cadi Ayyad University, Marrakech, Morocco;Laboratory of Immunology, Centre of Clinical Research, Mohammed VI<sup>th</sup> University Centre, Cadi Ayyad University, Marrakech, Mo-rocco;Polyvalent Intensive Care Unit, Child and Mother Hospital, Mohammed VI<sup>th</sup> University Centre, Cadi Ayyad University, Marrakech, Morocco)
