摘要
Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.
Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.
作者
Mohsin Ahmed
Golam Morshed
Mahmood Hasan Khan
Md. Arifur Rahman
Muhammed Aminur Razzaque
Shariful Islam
Sayeedur Rahman Khan
Chowdhury Md. Kudrat-E-Khuda
Salahuddin Anis Shiblee
Md. Habibur Rahman
Mohsin Ahmed;Golam Morshed;Mahmood Hasan Khan;Md. Arifur Rahman;Muhammed Aminur Razzaque;Shariful Islam;Sayeedur Rahman Khan;Chowdhury Md. Kudrat-E-Khuda;Salahuddin Anis Shiblee;Md. Habibur Rahman(Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh;Department of Cardiology, Government Employee’s Hospital, Dhaka, Bangladesh;Department of Cardiology, Delta Hospital Ltd., Dhaka, Bangladesh;IPDI Foundation, Dhaka, Bangladesh)