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Origins and Mechanisms in the Development of Major Mental Disorders: A Clinical Approach

Origins and Mechanisms in the Development of Major Mental Disorders: A Clinical Approach
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摘要 This paper considers the following collective significance of the shared, clinical characteristics of the major mental disorders (MMDs), their co-morbidities, overlaps and pharmacological responses with the following conclusions: 1) These disorders have a common, initial, neurodevelopmental origin. 2) They can occur probabilistically on susceptible individuals, on account of pre-existing, extreme, temperamental variances-signifying underlying structural variance. 3) Each of these syndromes can be considered the expression of disturbances in the overall, common, operating mode of brain function which normally ensures the synchrony, coordination, elegance and subtlety in the expression of all the brain’s higher faculties. 4) Lastly, this function is a complex, emergent phenomenon based on the individual’s temperamental/structural underlying makeup, switching intermittently from a normal phase to a pathologically, ordered one-the latter phase expressing itself with symptoms made up of expressing either/or, antithetical substitutes for each of the MMDs-similar to the fluctuations found in patient’s with Parkinson’s disease. This paper considers the following collective significance of the shared, clinical characteristics of the major mental disorders (MMDs), their co-morbidities, overlaps and pharmacological responses with the following conclusions: 1) These disorders have a common, initial, neurodevelopmental origin. 2) They can occur probabilistically on susceptible individuals, on account of pre-existing, extreme, temperamental variances-signifying underlying structural variance. 3) Each of these syndromes can be considered the expression of disturbances in the overall, common, operating mode of brain function which normally ensures the synchrony, coordination, elegance and subtlety in the expression of all the brain’s higher faculties. 4) Lastly, this function is a complex, emergent phenomenon based on the individual’s temperamental/structural underlying makeup, switching intermittently from a normal phase to a pathologically, ordered one-the latter phase expressing itself with symptoms made up of expressing either/or, antithetical substitutes for each of the MMDs-similar to the fluctuations found in patient’s with Parkinson’s disease.
出处 《Journal of Behavioral and Brain Science》 2012年第2期269-275,共7页 行为与脑科学期刊(英文)
关键词 TEMPERAMENT MAJOR MENTAL DISORDERS COMORBIDITY SYMPTOMATOLOGY Oscillations Synchrony Operating Mode Temperament Major Mental Disorders Comorbidity Symptomatology Oscillations Synchrony Operating Mode
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