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The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma

The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma
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摘要 Medulloblastoma (MB) is common tumor of the central nervous system in children. It’s reported that PI3K/AKT and Wnt signal pathway have important roles in MB. This study aims to investigate the expression of PI3K, AKT, Β-catenin and VEGFR-2 in MB to find a new pathway for MB. A total of 33 MB and 17 control brain cases were retrospectively evaluate d for PI3K, AKT, β-catenin and VEGFR-2 expression by immunohistochemical staining, and the relationship with clinical feature were analyzed. The positive rate of PI3K, AKT, β-catenin and VEGFR-2 in 33 MB were significantly greater than those in control group Medulloblastoma (MB) is common tumor of the central nervous system in children. It’s reported that PI3K/AKT and Wnt signal pathway have important roles in MB. This study aims to investigate the expression of PI3K, AKT, Β-catenin and VEGFR-2 in MB to find a new pathway for MB. A total of 33 MB and 17 control brain cases were retrospectively evaluate d for PI3K, AKT, β-catenin and VEGFR-2 expression by immunohistochemical staining, and the relationship with clinical feature were analyzed. The positive rate of PI3K, AKT, β-catenin and VEGFR-2 in 33 MB were significantly greater than those in control group (P
作者 Xiao Lin Yu Li
机构地区 Department of Pathology Chongqing Key Laboratory of Neurobiology Institute of Neuroscience
出处 《Journal of Biosciences and Medicines》 2017年第3期32-38,共7页 生物科学与医学（英文）
关键词 PI3K AKT Β-CATENIN VEGFR2 MEDULLOBLASTOMA PI3K AKT β-Catenin VEGFR2 Medulloblastoma
分类号 R73 [医药卫生—肿瘤]
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共引文献14

Journal of Biosciences and Medicines
2017年 第3期

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