摘要
<strong>Background:</strong> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The incidence of prostate cancer in Cameroon has been in</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">creasing in an alarming rate. The aim of this study is to characterize the form of prostate cancer and associated factors in patients from Cameroon Northern Regions. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> All patients with positive prostate biopsy (cancer+) from June 2018 to November 2019 were studied (n = 177). The followings were retrieved: digital rectal examination, standard clinical examinations, laboratory data such as serum prostate-specific antigen (PSA) level, and the Gleason score. Patients self-administered a questionnaire assessing prostate cancer’s risk factors. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Patients were mainly from the Far North region (36.72%), and were either farmers or breeders (48.01%). Only prostate adenocarcinoma was present, with predominance of aggressive forms (Gleason score ≥</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">7). Significant relationships were observed between Gleason score and 1) patients’ age (P = 0.006), 2) history of urinary tract infections (P = 0.015) and of exposure to agricultural products (P = 0.049), 3) clinical signs (nycturia, pollakiuria, poor acute urine retention, and dysuria) (P = 0.019), </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">4</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">) prostate weight, and </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">5</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">) serum PSA levels (P < 0.0001). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Aggressive forms of adenocarcinoma are the main prostate cancer in these regions, underlining the need for strategies aimed at raising prostate cancer awareness and early detection.</span></span></span></span>
<strong>Background:</strong> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The incidence of prostate cancer in Cameroon has been in</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">creasing in an alarming rate. The aim of this study is to characterize the form of prostate cancer and associated factors in patients from Cameroon Northern Regions. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> All patients with positive prostate biopsy (cancer+) from June 2018 to November 2019 were studied (n = 177). The followings were retrieved: digital rectal examination, standard clinical examinations, laboratory data such as serum prostate-specific antigen (PSA) level, and the Gleason score. Patients self-administered a questionnaire assessing prostate cancer’s risk factors. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Patients were mainly from the Far North region (36.72%), and were either farmers or breeders (48.01%). Only prostate adenocarcinoma was present, with predominance of aggressive forms (Gleason score ≥</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">7). Significant relationships were observed between Gleason score and 1) patients’ age (P = 0.006), 2) history of urinary tract infections (P = 0.015) and of exposure to agricultural products (P = 0.049), 3) clinical signs (nycturia, pollakiuria, poor acute urine retention, and dysuria) (P = 0.019), </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">4</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">) prostate weight, and </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">5</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">) serum PSA levels (P < 0.0001). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Aggressive forms of adenocarcinoma are the main prostate cancer in these regions, underlining the need for strategies aimed at raising prostate cancer awareness and early detection.</span></span></span></span>
作者
Tagne Simo Richard
Mohamadou Ahmadou
Nwabo Kamdje Armel Hervé
Seke Etet Paul Faustin
Baiguerel Erika Myriam
Danki Sillong Franklin
Telefo Phelix Bruno
Tagne Simo Richard;Mohamadou Ahmadou;Nwabo Kamdje Armel Hervé;Seke Etet Paul Faustin;Baiguerel Erika Myriam;Danki Sillong Franklin;Telefo Phelix Bruno(Department of Biomedical Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon;Department of Physiological Sciences and Biochemistry, FMBS, Garoua, University of Ngaoundere, Ngaoundere, Cameroon;Islamic Clinic of Adamawa, Ngaoundere, Cameroon;Department of Biochemistry, University of Dschang, Dschang, Cameroon)