摘要
Lipstick is the most widely used cosmetic product. Although lipstick gives a lot of social, psychological and therapeutic benefits, it may harm the consumers. Because most lipsticks contained high lead level and long term use of high lead level lipstick may harm the consumers. Research findings have suggested that administration of various antioxidants can prevent or subdue various toxic effects of lead and generation of oxidative stress. <strong><em>Hylocereus polyrhizus</em></strong> (Red dragon fruit) is widely available in Myanmar and it contains powerful antioxidant amaranth colorant called betacyanin pigment. It can prevent the oxidative stress caused by low level of lead, thus suitable as natural colorant for lipstick. As a role of pharmacist, this research was intended to minimize the adverse effects of lipsticks by formulating natural lipstick with betacyanin pigment obtained from <strong><em>H. polyrhizus</em></strong> and other natural ingredients. Formulation of lipstick was carried out by heating and blending method with homogenizer at a speed of 12000 rpm. Then, pH, melting point, surface abnormalities, aging stability, perfume stability and antioxidant activity were performed as quality evaluation. Skin irritation test, microbial analysis and lead content determination were carried out as safety evaluation. Formulated lipsticks with betacyanin pigment of <em><strong>H. polyrhizus</strong></em> have acceptable quality. The IC50 of standard ascorbic acid and formulated lipstick were 4.51 μg/ml and 22.23 μg/ml respectively. In quantitative analysis for microbiological control, formulated lipstick had no visible colony and in qualitative analysis, <strong><em>Staphylococcus aureus</em></strong>, <strong><em>E. coli</em></strong> and <strong><em>Pseudomonas aeruginosa</em></strong> were not detected in 0.5 g of formulated lipsticks. Moreover, lead content of formulated lipstick was only 2.9 ppm that is within allowable limit and it had negligible skin irritancy. Therefore, lipstick with betacyanin pigment of <em><strong>H. polyrhizus</strong></em> can utilize as Cosmeceutical.
Lipstick is the most widely used cosmetic product. Although lipstick gives a lot of social, psychological and therapeutic benefits, it may harm the consumers. Because most lipsticks contained high lead level and long term use of high lead level lipstick may harm the consumers. Research findings have suggested that administration of various antioxidants can prevent or subdue various toxic effects of lead and generation of oxidative stress. <strong><em>Hylocereus polyrhizus</em></strong> (Red dragon fruit) is widely available in Myanmar and it contains powerful antioxidant amaranth colorant called betacyanin pigment. It can prevent the oxidative stress caused by low level of lead, thus suitable as natural colorant for lipstick. As a role of pharmacist, this research was intended to minimize the adverse effects of lipsticks by formulating natural lipstick with betacyanin pigment obtained from <strong><em>H. polyrhizus</em></strong> and other natural ingredients. Formulation of lipstick was carried out by heating and blending method with homogenizer at a speed of 12000 rpm. Then, pH, melting point, surface abnormalities, aging stability, perfume stability and antioxidant activity were performed as quality evaluation. Skin irritation test, microbial analysis and lead content determination were carried out as safety evaluation. Formulated lipsticks with betacyanin pigment of <em><strong>H. polyrhizus</strong></em> have acceptable quality. The IC50 of standard ascorbic acid and formulated lipstick were 4.51 μg/ml and 22.23 μg/ml respectively. In quantitative analysis for microbiological control, formulated lipstick had no visible colony and in qualitative analysis, <strong><em>Staphylococcus aureus</em></strong>, <strong><em>E. coli</em></strong> and <strong><em>Pseudomonas aeruginosa</em></strong> were not detected in 0.5 g of formulated lipsticks. Moreover, lead content of formulated lipstick was only 2.9 ppm that is within allowable limit and it had negligible skin irritancy. Therefore, lipstick with betacyanin pigment of <em><strong>H. polyrhizus</strong></em> can utilize as Cosmeceutical.
作者
Theeoo Lwin
Cho Yi Myint
Htet Htet Win
Wah Wah Oo
Khit Chit
Theeoo Lwin;Cho Yi Myint;Htet Htet Win;Wah Wah Oo;Khit Chit(Department of Pharmacology, University of Pharmacy-Mandalay, Mandalay, Myanmar;Department of Pharmaceutics, University of Pharmacy-Mandalay, Mandalay, Myanmar;Biotechnology Research Department, Kyaukse, Myanmar;Department of Food and Drug Administration, Mandalay, Myanmar;Department of Food and Drug Administration, Naypyidaw, Myanmar)
