摘要
<b><span style="font-family:Verdana;">Introduction:</span></b><span style="font-family:Verdana;"> Hepatitis B Virus (HBV) and Human Immunodeficiency Virus </span><span style="font-family:Verdana;">(HIV) infection is a public health problem worldwide, particularly in sub-Saharan </span><span style="font-family:""><span style="font-family:Verdana;">Africa. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> to compare the epidemiological, clinical and biological characteristic</span></span><span style="font-family:""><span style="font-family:Verdana;">s of chronic HBV and HIV infection in blood donors at the National Center for Blood Transfusion (NCBT) in Bangui. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b><span style="font-family:Verdana;"> This was an 8-month analytical cross-sectional study from August 10, 2011 to April 9, 2012. During this study, we consecutively enrolled consenting blood donors of both sexes in which the search for HBsAg and HIV infection was </span><span><span style="font-family:Verdana;">carried out. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> During the study period, 850 blood donors were collected</span></span><span style="font-family:Verdana;">. H</span><span style="font-family:Verdana;">BsAg was found in 142 donors (16.7%), of whom 55 blood donors (6.5%</span><span style="font-family:Verdana;">) were coinfected with HIV. On the other hand, HIV serology was positive in 77 blood donors (9.1%) including 55 co-infected (6.5%) with HBV. In order to better compare the risk factors, we have not included HIV-HBV coinfected patients. Only 795 blood donors were selected for the risk factor study. There were 87 cases of HBsAg positive (10.9%) and 22 cases of HIV positive (2.8%). </span><span style="font-family:Verdana;">The average age of HIV and HBV infected patients was 25.7 and 26.2 years</span><span style="font-family:Verdana;">, </span><span style="font-family:Verdana;">respectively. Twelve blood donors (1.5%) over the age of 20 were HBsAg versu</span><span style="font-family:Verdana;">s 3 HIV positive blood donors (0.4%). Among blood donors over the age of 20, 75 (9.9%) were HBsAg positive, while 19 (2.4%) were HIV positive. Men were infected with HIV in 20 cases (2.5%), while those infected with HBV were 84 (10.6%). The risk factor found during HIV infection and HBV was unprotected sex with a p of 0.0038 and 0.0017 respectively. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The prevalence of HBV infection is higher than that of HIV among blood donors in </span><span style="font-family:Verdana;">Bangui. The setting up of a national viral hepatitis control program</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> which will</span><span style="font-family:Verdana;"> develop screening, treatment and vaccination actions could make the curve bend.
<b><span style="font-family:Verdana;">Introduction:</span></b><span style="font-family:Verdana;"> Hepatitis B Virus (HBV) and Human Immunodeficiency Virus </span><span style="font-family:Verdana;">(HIV) infection is a public health problem worldwide, particularly in sub-Saharan </span><span style="font-family:""><span style="font-family:Verdana;">Africa. </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> to compare the epidemiological, clinical and biological characteristic</span></span><span style="font-family:""><span style="font-family:Verdana;">s of chronic HBV and HIV infection in blood donors at the National Center for Blood Transfusion (NCBT) in Bangui. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b><span style="font-family:Verdana;"> This was an 8-month analytical cross-sectional study from August 10, 2011 to April 9, 2012. During this study, we consecutively enrolled consenting blood donors of both sexes in which the search for HBsAg and HIV infection was </span><span><span style="font-family:Verdana;">carried out. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> During the study period, 850 blood donors were collected</span></span><span style="font-family:Verdana;">. H</span><span style="font-family:Verdana;">BsAg was found in 142 donors (16.7%), of whom 55 blood donors (6.5%</span><span style="font-family:Verdana;">) were coinfected with HIV. On the other hand, HIV serology was positive in 77 blood donors (9.1%) including 55 co-infected (6.5%) with HBV. In order to better compare the risk factors, we have not included HIV-HBV coinfected patients. Only 795 blood donors were selected for the risk factor study. There were 87 cases of HBsAg positive (10.9%) and 22 cases of HIV positive (2.8%). </span><span style="font-family:Verdana;">The average age of HIV and HBV infected patients was 25.7 and 26.2 years</span><span style="font-family:Verdana;">, </span><span style="font-family:Verdana;">respectively. Twelve blood donors (1.5%) over the age of 20 were HBsAg versu</span><span style="font-family:Verdana;">s 3 HIV positive blood donors (0.4%). Among blood donors over the age of 20, 75 (9.9%) were HBsAg positive, while 19 (2.4%) were HIV positive. Men were infected with HIV in 20 cases (2.5%), while those infected with HBV were 84 (10.6%). The risk factor found during HIV infection and HBV was unprotected sex with a p of 0.0038 and 0.0017 respectively. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The prevalence of HBV infection is higher than that of HIV among blood donors in </span><span style="font-family:Verdana;">Bangui. The setting up of a national viral hepatitis control program</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> which will</span><span style="font-family:Verdana;"> develop screening, treatment and vaccination actions could make the curve bend.