摘要
<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">Hepatocellular carcinoma is the third leading cause of tumor </span><span style="font-family:Verdana;">related mortality and develops mostly in patients with chronic liver disease and</span><span style="font-family:;" "=""> <span style="font-family:Verdana;">liver cirrhosis. Human hepatocyte growth factor (HGF) is produced in various</span> <span style="font-family:Verdana;">organs of the body and is characterized as a multifunctional factor with vari</span><span style="font-family:Verdana;">ous biologic activities. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> Our aim was to investigate the predictive factors of </span><span style="font-family:Verdana;">recurrence specially the role of HGF in patients with HCC treated with TACE. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b><span style="font-family:Verdana;"> one hundred HCC patients treated by TACE who </span><span style="font-family:Verdana;">achieved complete response were included and divided into two groups a</span><span style="font-family:Verdana;">ccording to disease free survival (DFS) status at 1 year: the non</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">early recurrence</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (NER) group (1) and the early recurrence (ER) group (2). Univariate binary logistic regression analysis for the possible risk factors of recurrence showed that AFP, multinodularity and HGF level were significant. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> high </span><span style="font-family:Verdana;">AFP, multinodularity and high HGF were inter-related possible risk factor</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> for</span><span style="font-family:Verdana;"> 1-year recurrence of HCC in patients with initial remission following TACE</span><span style="font-family:Verdana;">.</span>
<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">Hepatocellular carcinoma is the third leading cause of tumor </span><span style="font-family:Verdana;">related mortality and develops mostly in patients with chronic liver disease and</span><span style="font-family:;" "=""> <span style="font-family:Verdana;">liver cirrhosis. Human hepatocyte growth factor (HGF) is produced in various</span> <span style="font-family:Verdana;">organs of the body and is characterized as a multifunctional factor with vari</span><span style="font-family:Verdana;">ous biologic activities. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> Our aim was to investigate the predictive factors of </span><span style="font-family:Verdana;">recurrence specially the role of HGF in patients with HCC treated with TACE. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b><span style="font-family:Verdana;"> one hundred HCC patients treated by TACE who </span><span style="font-family:Verdana;">achieved complete response were included and divided into two groups a</span><span style="font-family:Verdana;">ccording to disease free survival (DFS) status at 1 year: the non</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">early recurrence</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (NER) group (1) and the early recurrence (ER) group (2). Univariate binary logistic regression analysis for the possible risk factors of recurrence showed that AFP, multinodularity and HGF level were significant. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> high </span><span style="font-family:Verdana;">AFP, multinodularity and high HGF were inter-related possible risk factor</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> for</span><span style="font-family:Verdana;"> 1-year recurrence of HCC in patients with initial remission following TACE</span><span style="font-family:Verdana;">.</span>
作者
Amr Mohamed Zaghloul
Ahmed Sedky
Ali Hussein Mohammed
Samer A. El-Sawy
Ahmed Abd El Rady Ahmed
Emad Eldin Nabil
Amr Mohamed Zaghloul;Ahmed Sedky;Ali Hussein Mohammed;Samer A. El-Sawy;Ahmed Abd El Rady Ahmed;Emad Eldin Nabil(Tropical Medicine and Gastroenterology Department, Sohag University, Sohag, Egypt;Department of Clinical Pathology, Sohag University, Sohag, Egypt;Department of Internal Medicine, Sohag University, Sohag, Egypt;Biochemistry Department, Sohag University, Sohag, Egypt;Interventional Radiology Department, Alazhar University (Assuit Branch), Assuit, Egypt;Department of Oncology, Sohag University, Sohag, Egypt)
