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Expression and Clinical Significance of Ki67 in Common Gastrointestinal Tumours

Expression and Clinical Significance of Ki67 in Common Gastrointestinal Tumours
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摘要 Ki67 is a marker of cell proliferation that is expressed in the S, G2 and M phases but not in the G0 phase of the cell cycle. Several recent studies showed that the expression of Ki67 is closely related to the occurrence and development of gastrointestinal tumours. The Ki67 index is closely related to the degree of differentiation, invasion, metastasis and prognosis of gastrointestinal tumours. This review describes the relationship between the Ki67 index and degree of malignancy, therapeutic effect and prognosis of gastrointestinal tumours. Ki67 is a marker of cell proliferation that is expressed in the S, G2 and M phases but not in the G0 phase of the cell cycle. Several recent studies showed that the expression of Ki67 is closely related to the occurrence and development of gastrointestinal tumours. The Ki67 index is closely related to the degree of differentiation, invasion, metastasis and prognosis of gastrointestinal tumours. This review describes the relationship between the Ki67 index and degree of malignancy, therapeutic effect and prognosis of gastrointestinal tumours.
作者 Fangyu Shi Yunnan Dai Yiying Bai Qingshan Li Fangyu Shi;Yunnan Dai;Yiying Bai;Qingshan Li(Affiliated Hospital of Chengde Medical University, Chengde, China)
机构地区 Affiliated Hospital of Chengde Medical University
出处 《Open Journal of Gastroenterology》 2021年第12期295-306,共12页 肠胃病学期刊（英文）
关键词 Gastrointestinal Neoplasms KI67 Pathological Features PROGNOSIS Gastrointestinal Neoplasms Ki67 Pathological Features Prognosis
分类号 R73 [医药卫生—肿瘤]
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  • 1马静,魏素菊,王俊艳,刘巍,刘风铃,姜达.BRCA1、TopoⅡα、Bcl-2在三阴乳腺癌中的表达及对预后的影响[J].中国老年学杂志,2014,34(7):1811-1813. 被引量：6
  • 2Atsushi Tashiro,Masatoshi Sano,Koichi Kinameri,Kazutaka Fujita,Yutaka Takeuchi.Comparing mass screening techniques for gastric cancer in Japan[J].World Journal of Gastroenterology,2006,12(30):4873-4874. 被引量：24
  • 3Chao Tian,Zong-Guang Zhou,Wen-Jian Meng,Xiao-Feng Sun,Yong-Yang Yu,Li Li,Hong-Zhi Luo,,Lie Yang,Bin Zhou,Jun Gu.Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients[J].World Journal of Gastroenterology,2007,13(28):3878-3882. 被引量：11
  • 4孙喜斌,刘志才,刘曙正,李变云,戴涤新,全培良,程兰平,陆建邦.林州市食管癌和胃癌的发病水平及变化趋势[J].中华肿瘤杂志,2007,29(10):764-767. 被引量：22
  • 5GerdesJ, SchwabU, LemkeH, et al. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation[J]. Int J Cancer, 1983, 31(1): 13-20.
  • 6GoldhirschA, IngleJN, GelberRD, et al. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009[J]. Ann Oncol, 2009, 20(8): 1319-1329.
  • 7FonatschC, DuchrowM, RiederH, et al. Assignment of the human Ki-67 gene (MK167) to 10q25-qter[J]. Genomics, 1991, 11(2): 476-477.
  • 8Harper-WynneC, RossG, SacksN, et al. Effects of the aromatase inhibitor letrozole on normal breast epithelial cell proliferation and metabolic indices in postmenopausal women: a pilot study for breast cancer prevention[J]. Cancer Epidemiol Biomarkers Prev, 2002, 11(7): 614-621.
  • 9ShokerBS, JarvisC, DaviesMP, et al. Immunodetectable cyclin D(1) is associated with oestrogen receptor but not Ki67 in normal,cancerous and precancerous breast lesions[J]. Br J Cancer, 2001, 84(8): 1064-1069.
  • 10BhatavdekarJM, PatelDD, ShahNG, et al. Prognostic significance of immunohistochemically localized biomarkers in stage Ⅱ and stage Ⅲ breast cancer: a multivariate analysis[J]. Ann Surg Oncol, 2000, 7(4): 305-311.

共引文献1655

Open Journal of Gastroenterology
2021年 第12期

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