摘要
Introduction: Helicobacter pylori (Hp) infection is a worldwide public health problem. Unfortunately, its management poses a problem because of resistance to antibiotics. However, there are codified treatment protocols covering sequential and concomitant quadritherapy with regard to first-line probabilistic treatment. The objective of this study was to assess the therapeutic efficacy of these 2 treatment regimens in the management of Hp infection at Kinshasa. Methods: This was a mixed study, with documentary, descriptive and interventional approaches, carried out between September 1, 2018 and April 30, 2020. Results: Sixty-four patients were collected, including 36 men against 28 women with a sex ratio of 1H:1F;the mean age was 54 ± 16.5 years. There was an over-representation of senior patients (n = 29);an intermediate number of adult patients (n = 22) and a lower number of young patients (n = 13). 34 and 30 were respectively treated according to the concomitant and sequential regimens. Concomitant quadruple therapy offered an eradication rate of 91.2% compared to 56.7% for sequential quadruple therapy;concomitant treatment, advancing age and absence of risky behavior more quickly predicted the occurrence of eradication success. Conclusion: The present study showed superiority of concomitant quadruple therapy over sequential quadruple therapy in first-line treatment. Alcohol with active smoking had a negative influence, while concomitant quadruple therapy, advancement in age had a positive influence on the success of the eradication of Hp infection.
Introduction: Helicobacter pylori (Hp) infection is a worldwide public health problem. Unfortunately, its management poses a problem because of resistance to antibiotics. However, there are codified treatment protocols covering sequential and concomitant quadritherapy with regard to first-line probabilistic treatment. The objective of this study was to assess the therapeutic efficacy of these 2 treatment regimens in the management of Hp infection at Kinshasa. Methods: This was a mixed study, with documentary, descriptive and interventional approaches, carried out between September 1, 2018 and April 30, 2020. Results: Sixty-four patients were collected, including 36 men against 28 women with a sex ratio of 1H:1F;the mean age was 54 ± 16.5 years. There was an over-representation of senior patients (n = 29);an intermediate number of adult patients (n = 22) and a lower number of young patients (n = 13). 34 and 30 were respectively treated according to the concomitant and sequential regimens. Concomitant quadruple therapy offered an eradication rate of 91.2% compared to 56.7% for sequential quadruple therapy;concomitant treatment, advancing age and absence of risky behavior more quickly predicted the occurrence of eradication success. Conclusion: The present study showed superiority of concomitant quadruple therapy over sequential quadruple therapy in first-line treatment. Alcohol with active smoking had a negative influence, while concomitant quadruple therapy, advancement in age had a positive influence on the success of the eradication of Hp infection.
作者
Antoine Tshimpi
Patrick de Jésus Ngoma-Kisoko
Aurore Beia
Tressy Kalenga-Ngomba
Jacqueline Nkondi
Fabrice Bokabanja
Heritier Mawalala
Trésor Monsere
Pitshou Kengibe
Mireille Nganga Nkanga
Benjamin Longo-Mbenza
Antoine Tshimpi;Patrick de Jésus Ngoma-Kisoko;Aurore Beia;Tressy Kalenga-Ngomba;Jacqueline Nkondi;Fabrice Bokabanja;Heritier Mawalala;Trésor Monsere;Pitshou Kengibe;Mireille Nganga Nkanga;Benjamin Longo-Mbenza(Department of Internal medicine, Cliniques Universitaires de Kinshasa, University of Kinshasa, Kinshasa, DR Congo;Foundation Aurore, Kinshasa, DR Congo;University Catholique of Bukavu, Bukavu, DR Congo;Department of Medical Biologie, Cliniques Universitaires de Kinshasa, University of Kinshasa, Kinshasa, DR Congo;Lomo University of Research, Kinshasa, DR Congo)
