摘要
<strong>Purpose: </strong><span style="font-family:Verdana;">Cervical cancer is still one of the main causes of cancer and mortality in women, especially in low- and middle-income countries, although it is a completely preventable disease through the detection and treatment of pre-cancer lesions.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">We evaluated the efficacy and tolerability of thermocoagulation treatment of high-grade cervical intraepithelial neoplasia (CIN 2 and 3). </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We evaluated 115 women with high-grade cervical intraepithelial neoplasia, 54 with CIN 2 and 61 with CIN 3, confirmed by biopsy and without previous treatment, from January 2016 to December 2018, undergoing thermocoagulation treatment at the Lower Genital Tract Pathology and Colposcopy Service of the Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The mean age was 33.11 years (SD</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">9.83) for CIN 2 and 35.28 years (SD</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">7.97) for CIN 3 patients. Treatment efficacy was 90.8% in CIN 2 and 94.9% in CIN 3 cases. Pain was the main symptom reported at the time of treatment, occurring more frequently in the CIN 3 group (49.1% versus 27.8% in the CIN 2 group). As the more important long-term complication, there were 3 cases of pelvic inflammatory disease in CIN 2 (5.6%) and 3 in CIN 3 group (5.0%). The percentage of residual lesion was very low in both groups, 5 in CIN 2 group (9.2%) and 2 in CIN 3 group (3.4%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Thermocoagulation is an effective method for </span></span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">treatment of cervical pre-cancer lesions (CIN 2 and CIN 3), with a low risk of adverse events and complications.</span>
<strong>Purpose: </strong><span style="font-family:Verdana;">Cervical cancer is still one of the main causes of cancer and mortality in women, especially in low- and middle-income countries, although it is a completely preventable disease through the detection and treatment of pre-cancer lesions.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">We evaluated the efficacy and tolerability of thermocoagulation treatment of high-grade cervical intraepithelial neoplasia (CIN 2 and 3). </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We evaluated 115 women with high-grade cervical intraepithelial neoplasia, 54 with CIN 2 and 61 with CIN 3, confirmed by biopsy and without previous treatment, from January 2016 to December 2018, undergoing thermocoagulation treatment at the Lower Genital Tract Pathology and Colposcopy Service of the Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The mean age was 33.11 years (SD</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">9.83) for CIN 2 and 35.28 years (SD</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">7.97) for CIN 3 patients. Treatment efficacy was 90.8% in CIN 2 and 94.9% in CIN 3 cases. Pain was the main symptom reported at the time of treatment, occurring more frequently in the CIN 3 group (49.1% versus 27.8% in the CIN 2 group). As the more important long-term complication, there were 3 cases of pelvic inflammatory disease in CIN 2 (5.6%) and 3 in CIN 3 group (5.0%). The percentage of residual lesion was very low in both groups, 5 in CIN 2 group (9.2%) and 2 in CIN 3 group (3.4%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Thermocoagulation is an effective method for </span></span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">treatment of cervical pre-cancer lesions (CIN 2 and CIN 3), with a low risk of adverse events and complications.</span>
作者
Beatriz Maykot Kuerten
Paulo Sérgio Viero Naud
Francisco Jose Cidral-Filho
Armando José D’Acampora
Beatriz Maykot Kuerten;Paulo Sérgio Viero Naud;Francisco Jose Cidral-Filho;Armando José D’Acampora(Department of Obstetrics and Gynecology, Federal University of Santa Catarina, Florianópolis, Brazil;Department of Obstetrics and Gynecology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;Experimental Neuroscience Laboratory (LaNEx), Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Florianópolis, Brazil;Department of Clinical Surgery, Federal University of Santa Catarina, Florianópolis, Brazil)