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Dysplastic Gangliocytoma: A Rare Example of Cerebellar Tumor with An Evident Genetic Profile (Cowden Syndrome)

Dysplastic Gangliocytoma: A Rare Example of Cerebellar Tumor with An Evident Genetic Profile (Cowden Syndrome)
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摘要 <div style="text-align:justify;"> <span style="font-family:Verdana;"><strong>Objective:</strong> To describe the histological and immunohistochemical findings observed when studying a dysplastic cerebellar gangliocytoma observed in a 33-year-old man with a history of Thyroid Cancer. <strong>Material and Methods:</strong> Radiological images (MRI) and histological and immunohistochemical preparations obtained from the cerebellar tissue were received in our laboratory. <strong>Results:</strong> A neoplasm constituted by aberrant-looking mature neurons was observed that showed negativity for the immunohistochemical markers of the PTEN protein, expression of the activity of the PTEN gene. <strong>Conclusions:</strong> Verify the diagnosis of a rare entity, clearly related in scientific publications with Cowden’s Syndrome.</span> </div> <div style="text-align:justify;"> <span style="font-family:Verdana;"><strong>Objective:</strong> To describe the histological and immunohistochemical findings observed when studying a dysplastic cerebellar gangliocytoma observed in a 33-year-old man with a history of Thyroid Cancer. <strong>Material and Methods:</strong> Radiological images (MRI) and histological and immunohistochemical preparations obtained from the cerebellar tissue were received in our laboratory. <strong>Results:</strong> A neoplasm constituted by aberrant-looking mature neurons was observed that showed negativity for the immunohistochemical markers of the PTEN protein, expression of the activity of the PTEN gene. <strong>Conclusions:</strong> Verify the diagnosis of a rare entity, clearly related in scientific publications with Cowden’s Syndrome.</span> </div>
作者 Javier Ortiz Rodríguez-Parets Luis Miguel Chinchilla Tábora Enrique Montero Mateos Elisa Muñoz Torres María Dolores Ludeña de la Cruz Javier Ortiz Rodríguez-Parets;Luis Miguel Chinchilla Tábora;Enrique Montero Mateos;Elisa Muñoz Torres;María Dolores Ludeña de la Cruz(Department of Pathology, University Hospital of Salamanca (Spain), Salamanca, Spain;Department of Cell Biology and Pathology, The Medical School University of Salamanca, Salamanca, Spain)
出处 《Open Journal of Pathology》 2021年第2期33-37,共5页 病理学期刊(英文)
关键词 Dysplastic Gangliocytoma IMMUNOHISTOCHEMISTRY Cowden Syndrome Dysplastic Gangliocytoma Immunohistochemistry Cowden Syndrome
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