摘要
Cerebral aspergillosis commonly affects immunocompromised hosts, primarily patients on immunosuppressive therapy and those with acquired or immunodeficient states such as AIDS. We report a case of cerebral aspergillosis in a 39-year-old woman with a history of treated chronic lymphocytic leukemia (CLL). Multiple fragments of fixed tissues with formalin were freshly sent to the laboratory. An extemporaneous examination was performed by spreading. The rest of the sample was embedded in paraffin and studied according to the standard histological method with special stains and an immunohistochemical study. A microscopic observation showed abundant clusters of tangled mycelial filaments, Grocott+. At the edge, a nervous tissue was observed remodeled by an abundant inflammatory infiltrate consisting essentially of small lymphocytes and plasma cells. Additional immunohistochemistry was performed using anti-CD20, anti-CD3, anti-CD5, anti-CD23, anti-Bcl2, anti-Ki67, anti-IgD and anti-Kappa and Lamda antibodies. All taken together there were no further founding in support of a secondary localization of CLL. Cerebral aspergillosis is quite rare and often occurs in a context of immunosuppression. This case indicates the importance of a close collaboration between clinicians and pathologists for optimal patient care.
Cerebral aspergillosis commonly affects immunocompromised hosts, primarily patients on immunosuppressive therapy and those with acquired or immunodeficient states such as AIDS. We report a case of cerebral aspergillosis in a 39-year-old woman with a history of treated chronic lymphocytic leukemia (CLL). Multiple fragments of fixed tissues with formalin were freshly sent to the laboratory. An extemporaneous examination was performed by spreading. The rest of the sample was embedded in paraffin and studied according to the standard histological method with special stains and an immunohistochemical study. A microscopic observation showed abundant clusters of tangled mycelial filaments, Grocott+. At the edge, a nervous tissue was observed remodeled by an abundant inflammatory infiltrate consisting essentially of small lymphocytes and plasma cells. Additional immunohistochemistry was performed using anti-CD20, anti-CD3, anti-CD5, anti-CD23, anti-Bcl2, anti-Ki67, anti-IgD and anti-Kappa and Lamda antibodies. All taken together there were no further founding in support of a secondary localization of CLL. Cerebral aspergillosis is quite rare and often occurs in a context of immunosuppression. This case indicates the importance of a close collaboration between clinicians and pathologists for optimal patient care.
作者
Aimé Sosthène Ouédraogo
Franck Auguste Hermann Adémayali Ido
Ibrahim Savadogo
Souleymane Ouattara
Rakiswendé Alexis Ouédraogo
Assita Lamien Sanou
Olga Mélanie Lompo
Aimé Sosthène Ouédraogo;Franck Auguste Hermann Adémayali Ido;Ibrahim Savadogo;Souleymane Ouattara;Rakiswendé Alexis Ouédraogo;Assita Lamien Sanou;Olga Mélanie Lompo(Pathological Anatomy Service of Bogodogo Teaching University Hospital, Ouagadougou, Burkina Faso;UFR/SDS, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso;Pathological Anatomy Service of Tingandogo, Ouagadougou, Burkina Faso;Pathological Anatomy Service of Ouahigouya, Ouahigouya, Burkina Faso;Embryology, Cytogenetics and Reproductive Biology of Bogodogo Teaching University Hospital, Ouagadougou, Burkina Faso;Pathological Anatomy Service of Yalgado Ouédraogo, Ouagadougou, Burkina Faso)