摘要
<strong>Background:</strong><b><i><span style="font-family:""> </span></i></b><span style="font-family:Verdana;">Mechanical ventilation (MV) is one of the most common therapies in the neonatal Intensive Care Unit (NICU) and is associated with increased morbidity and mortality. MV is a complex and highly specialized area in neonatology that has several complications related to different modes, techniques, and devices.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Aim of the Study</span></b><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:Verdana;">To detect the causes of morbidity and mortality in mechanically ventilated neonates and to correlate the neonatal morbidity and mortality with gestational age, birth weight and duration of MV.</span><span style="font-family:""> </span><b><span style="font-family:""><span style="font-family:Verdana;">Patients and Methods:</span><i> </i></span></b><span style="font-family:Verdana;">This prospective observation analytical study was carried out on 110 neonates who were admitted to NICU at Al-Zahraa university hospital on MV during the period from March 2019 to March 2020. All neonates were followed up till the time of discharge with record of any complications during mechanical ventilation. Detailed medical history, examination to detect indication of MV and laboratory,</span><span style="font-family:""> </span><span style="font-family:Verdana;">radiological investigations were recorded.</span><span style="font-family:""> </span><span style="font-family:Verdana;">As regard the general characterization of studied neonates, 64 (58.2%) were males while the rest 46 (41.8%) were females, 50 (45.4%) were full term (37</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">42 wks), 42</span><span style="font-family:""> </span><span style="font-family:Verdana;">(38.18%) were early preterm (28</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">33</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">wks), 18 (16.3%) were late preterm</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">(34</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">42 wks</span><span style="font-family:Verdana;">). </span><b><span style="font-family:""><span style="font-family:Verdana;">Results:</span><i> </i></span></b><span style="font-family:Verdana;">Among </span><span style="font-family:Verdana;">(</span><span style="font-family:Verdana;">110 mechanically ventilated neonates</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> 58.2% were males, 41.8% were females. The most common indication for MV in the studied cases was respiratory distress syndrome (RDS) in 30% neonates. Ventilator associated pnemonia and Devices associated infection were the most common complications related to MV (19.1% and 11.8% respectively). While septic shock and multiorgan failure were the most common complications related to the underlying disease (24%). There is a significant negative association between gestational age, birth weight and mortality in mechanically ventilated neonates.</span><span style="font-family:""> </span><span style="font-family:Verdana;">the overall recovery was 59.1% among studied neonates.</span><span style="font-family:""> </span><b><span style="font-family:""><span style="font-family:Verdana;">Conclusion:</span><i> </i></span></b><span style="font-family:Verdana;">Respiratory disorders were the commonest indication of MV in NICU mostly RDS. Ventilator associated pneumonia and devices associated infection are common complications. Preterm and low birth weight neonates are vulnerable group for need of mechanical ventilation.</span>
<strong>Background:</strong><b><i><span style="font-family:""> </span></i></b><span style="font-family:Verdana;">Mechanical ventilation (MV) is one of the most common therapies in the neonatal Intensive Care Unit (NICU) and is associated with increased morbidity and mortality. MV is a complex and highly specialized area in neonatology that has several complications related to different modes, techniques, and devices.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Aim of the Study</span></b><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:Verdana;">To detect the causes of morbidity and mortality in mechanically ventilated neonates and to correlate the neonatal morbidity and mortality with gestational age, birth weight and duration of MV.</span><span style="font-family:""> </span><b><span style="font-family:""><span style="font-family:Verdana;">Patients and Methods:</span><i> </i></span></b><span style="font-family:Verdana;">This prospective observation analytical study was carried out on 110 neonates who were admitted to NICU at Al-Zahraa university hospital on MV during the period from March 2019 to March 2020. All neonates were followed up till the time of discharge with record of any complications during mechanical ventilation. Detailed medical history, examination to detect indication of MV and laboratory,</span><span style="font-family:""> </span><span style="font-family:Verdana;">radiological investigations were recorded.</span><span style="font-family:""> </span><span style="font-family:Verdana;">As regard the general characterization of studied neonates, 64 (58.2%) were males while the rest 46 (41.8%) were females, 50 (45.4%) were full term (37</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">42 wks), 42</span><span style="font-family:""> </span><span style="font-family:Verdana;">(38.18%) were early preterm (28</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">33</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">wks), 18 (16.3%) were late preterm</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">(34</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">42 wks</span><span style="font-family:Verdana;">). </span><b><span style="font-family:""><span style="font-family:Verdana;">Results:</span><i> </i></span></b><span style="font-family:Verdana;">Among </span><span style="font-family:Verdana;">(</span><span style="font-family:Verdana;">110 mechanically ventilated neonates</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> 58.2% were males, 41.8% were females. The most common indication for MV in the studied cases was respiratory distress syndrome (RDS) in 30% neonates. Ventilator associated pnemonia and Devices associated infection were the most common complications related to MV (19.1% and 11.8% respectively). While septic shock and multiorgan failure were the most common complications related to the underlying disease (24%). There is a significant negative association between gestational age, birth weight and mortality in mechanically ventilated neonates.</span><span style="font-family:""> </span><span style="font-family:Verdana;">the overall recovery was 59.1% among studied neonates.</span><span style="font-family:""> </span><b><span style="font-family:""><span style="font-family:Verdana;">Conclusion:</span><i> </i></span></b><span style="font-family:Verdana;">Respiratory disorders were the commonest indication of MV in NICU mostly RDS. Ventilator associated pneumonia and devices associated infection are common complications. Preterm and low birth weight neonates are vulnerable group for need of mechanical ventilation.</span>
作者
Aya Abdelkader Othman
Zeinab Farag Oshaib
Marwa El-Hady Abd El Moneim
Aya Abdelkader Othman;Zeinab Farag Oshaib;Marwa El-Hady Abd El Moneim(Bachelor of Medicine and Surgery, Mansoura University, Mansoura, Egypt;Pediatrics and Neonataology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt;Pediatric and Neonataology Department, Al Zahraa University Hospital, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt)