摘要
Objective: The present study consisted of challenging the extract of kombucha and the fungus Ganoderma reported as hypoglycemic and used as alternative treatments against diabetes on the number and morphology of islets of Langerhans. Material and Methods: 64 Wistar rats were used in 4 groups: one control, three experimental, streptozotocin, Kombucha y Ganoderma induced diabetes with streptozotocin. Divided into four post-induction stages at 2, 15, 30 and 45 days of treatment, sacrificing 4 rats at each stage, to perform the morphological analysis of the pancreas. Results: A decrease in the islets of Langerhans in size, volume and the number of cells within them was identified for the streptozotocin group from the second stage until almost disappearing due to diabetes, in the groups of Kombucha y Ganoderma the same was observed but they were recovered with the extract treatments and the average number of islets was similar in these groups, the group of Ganoderma. Conclusion: Under the conditions of this work, a protective and regenerative effect of both extracts is identified.
Objective: The present study consisted of challenging the extract of kombucha and the fungus Ganoderma reported as hypoglycemic and used as alternative treatments against diabetes on the number and morphology of islets of Langerhans. Material and Methods: 64 Wistar rats were used in 4 groups: one control, three experimental, streptozotocin, Kombucha y Ganoderma induced diabetes with streptozotocin. Divided into four post-induction stages at 2, 15, 30 and 45 days of treatment, sacrificing 4 rats at each stage, to perform the morphological analysis of the pancreas. Results: A decrease in the islets of Langerhans in size, volume and the number of cells within them was identified for the streptozotocin group from the second stage until almost disappearing due to diabetes, in the groups of Kombucha y Ganoderma the same was observed but they were recovered with the extract treatments and the average number of islets was similar in these groups, the group of Ganoderma. Conclusion: Under the conditions of this work, a protective and regenerative effect of both extracts is identified.
作者
Pedro Hinojosa-Gómez
Sergio Fausto-Guerra
Guillermo Nolasco-Rodríguez
Lucia García-Delgado
Víctor Barragán-Cano
Manuel Rosales-Cortés
Esther Albarrán-Rodríguez
José Ricardo Cuéllar-Pérez
Pedro Hinojosa-Gómez;Sergio Fausto-Guerra;Guillermo Nolasco-Rodríguez;Lucia García-Delgado;Víctor Barragán-Cano;Manuel Rosales-Cortés;Esther Albarrán-Rodríguez;José Ricardo Cuéllar-Pérez(Department of Veterinary Medicine, University Center for Agricultural Biological Sciences, University of Guadalajara, Jalisco, Mexico;Doctorate of Sciences in Ecophysiology and Genetic Resources, University Center for Agricultural Biological Sciences, University of Guadalajara, Jalisco, Mexico;Department of Botany and Zoology, University Center for Agricultural Biological Sciences, University of Guadalajara, Jalisco, Mexico)
