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The Research of Treg Cells: Progress and Challenge 被引量:6

The Research of Treg Cells: Progress and Challenge
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摘要 T regulatory cells (Tregs) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg could control and delay allograft rejection. Induction of immune tolerance decreases the risk of acute and chronic graft rejection after solid organ transplantation and can improve transplanted organ survival. Tregs are being tested in trials as a potential therapy in cell and solid organ transplantation. However, as we know, regulatory T cells (Tregs) are crucial for peripheral tolerance and are intimately involved in cancer. The influence of Tregs on cancer progression has been demonstrated in a large number of preclinical models and confirmed in several types of malignancies. Neoplastic processes trigger an increase of Treg numbers in draining lymph nodes, spleen, blood, and tumors, leading to the suppression of anti-tumor responses. In this review, we summarize some of the critical aspects of the immunoregulatory function of Treg cells in cancer and transplantation and discuss their potential research progress and challenge. T regulatory cells (Tregs) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg could control and delay allograft rejection. Induction of immune tolerance decreases the risk of acute and chronic graft rejection after solid organ transplantation and can improve transplanted organ survival. Tregs are being tested in trials as a potential therapy in cell and solid organ transplantation. However, as we know, regulatory T cells (Tregs) are crucial for peripheral tolerance and are intimately involved in cancer. The influence of Tregs on cancer progression has been demonstrated in a large number of preclinical models and confirmed in several types of malignancies. Neoplastic processes trigger an increase of Treg numbers in draining lymph nodes, spleen, blood, and tumors, leading to the suppression of anti-tumor responses. In this review, we summarize some of the critical aspects of the immunoregulatory function of Treg cells in cancer and transplantation and discuss their potential research progress and challenge.
作者 Jinguo Zhu
出处 《World Journal of Cardiovascular Diseases》 2015年第6期150-165,共16页 心血管病(英文)
关键词 TREG CELLS TRANSPLANTATION Immunoregulatory CANCER Immunoregulatory Treg Cells Transplantation Immunoregulatory Cancer Immunoregulatory
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  • 1Lan-JuanLi Zhong-WenWu Dang-ShengXiao Ji-FangSheng.Changes of gut flora and endotoxin in rats with D-galactosamine-induced acute liver failure[J].World Journal of Gastroenterology,2004,10(14):2087-2090. 被引量:19
  • 2赖力英,杨旭,许向青,蒋永芳,童敏.四氯化碳诱导大鼠急性肝功能衰竭动物模型的建立[J].中国现代医学杂志,2005,15(11):1655-1657. 被引量:25
  • 3郭韶梅,王爱平.CD8^+T细胞在慢性阻塞性肺疾病发病机制中的作用[J].国际呼吸杂志,2007,27(3):188-190. 被引量:9
  • 4张炜,罗芳军,周娇娇,陈玮琳.Th17细胞的研究进展[J].浙江大学学报(医学版),2007,36(6):620-625. 被引量:7
  • 5Moitra S,Puri R,Paul D,et al. Global perspectives of e- merging occupational and environmental lung diseases [J]. Current Opinion in Pulmonary Medicine,2015,21 (2): 114-120.
  • 6Marsland B J, Konigshoff M,Saglani S,et al. Immune system dysregulation in chronic lung disease [J]. European Respi- ratory Journal, 2011,38 (3) : 500-501.
  • 7Whiteside TL, Patrick S, Bastian S. Induced and natural regulatory T cells in human cancer [J]. Expert Opinion on Biological Therapy,2012, 12(10) : 1383-1397.
  • 8Kim HW,Cho SI,Bae S,et al. Vitamin C up-regulates expression of CD80,CD86 and MHC class 11 on dendrit- ic cell line,DC-1 via the activation of p38 MAPK [J]. Immune Network, 2012,12 (6) : 277-283.
  • 9Galasso T, Mazzetta A, Conio V, et al. Severe obstructive pattern mimicking an asthma exacerbation as first presentation of crack smoking:a case report [J]. Case Re- ports in Internal Medicine, 2015,2 (2) : 68-69.
  • 10Ismail AM,Aly SS, Fayed HM,et al. Serum 25-hydrox- yvitamin D and CD4+CD25 (+high)FoxP3+ regulatory T cell as predictors of severity of bronchial asthma in chil- dren [J]. Egyptian Journal of Immunology, 2015,22 ( 1 ) : 9-18.

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