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Guidelines for the Prevention of Symptomatic Cardiovascular Disease, Based upon the Presence of Coronary Artery Calcified Plaque—Provided by the Society for the Prevention of Symptomatic Heart Disease 被引量:3

Guidelines for the Prevention of Symptomatic Cardiovascular Disease, Based upon the Presence of Coronary Artery Calcified Plaque—Provided by the Society for the Prevention of Symptomatic Heart Disease
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摘要 Introduction: The epidemic of atherosclerotic cardiovascular disease in the Western World accounts for the majority of morbidity and mortality in adults. This disease is on the increase, and previous recommendations using “risk equations” to prescribe preventive treatment have not been successful in reducing the prevalence of cardiovascular disease. Furthermore, compliance with statin medication has been limited, with approximately 50% of individuals being non-compliant within five years. This situation is unacceptable since atherosclerosis is both preventable and reversible. Methods: The guidelines presented in this article utilize coronary artery calcium scanning as the basis for preventative therapeutic decisions and identifying the presence of asymptomatic cardiovascular disease. This radiographic technique is superior to “risk equations” in predicting future cardiovascular events. It provides a comprehensive assessment of the lifelong insults to the coronary artery vascular endothelium and the resulting inflammation. Coronary artery calcium scanning is widely available, inexpensive, safe, and reproducible. It has the major advantage of increasing treatment compliance in patients with positive coronary artery calcium scores. Results: All suggested guidelines are supported by published scientific data. Citations are provided to allow the reader to obtain further information. The authors are available for further consultation. Each guideline provides specific recommendations that the primary caregiver can discuss with the patient. Patient involvement in decision-making is strongly recommended. Both treatment costs and adverse effects are minimal. Conclusion: It is anticipated that the early identification of asymptomatic cardiovascular disease and its aggressive treatment will result in regression of subclinical atherosclerosis. Adoption of these guidelines will stop the epidemic of symptomatic heart disease and result in healthier and more satisfied patients. Introduction: The epidemic of atherosclerotic cardiovascular disease in the Western World accounts for the majority of morbidity and mortality in adults. This disease is on the increase, and previous recommendations using “risk equations” to prescribe preventive treatment have not been successful in reducing the prevalence of cardiovascular disease. Furthermore, compliance with statin medication has been limited, with approximately 50% of individuals being non-compliant within five years. This situation is unacceptable since atherosclerosis is both preventable and reversible. Methods: The guidelines presented in this article utilize coronary artery calcium scanning as the basis for preventative therapeutic decisions and identifying the presence of asymptomatic cardiovascular disease. This radiographic technique is superior to “risk equations” in predicting future cardiovascular events. It provides a comprehensive assessment of the lifelong insults to the coronary artery vascular endothelium and the resulting inflammation. Coronary artery calcium scanning is widely available, inexpensive, safe, and reproducible. It has the major advantage of increasing treatment compliance in patients with positive coronary artery calcium scores. Results: All suggested guidelines are supported by published scientific data. Citations are provided to allow the reader to obtain further information. The authors are available for further consultation. Each guideline provides specific recommendations that the primary caregiver can discuss with the patient. Patient involvement in decision-making is strongly recommended. Both treatment costs and adverse effects are minimal. Conclusion: It is anticipated that the early identification of asymptomatic cardiovascular disease and its aggressive treatment will result in regression of subclinical atherosclerosis. Adoption of these guidelines will stop the epidemic of symptomatic heart disease and result in healthier and more satisfied patients.
作者 David S. Schade Scott Obenshain Martin Hickey Jennifer Febbo Samuel Wann Robert Philip Eaton David S. Schade;Scott Obenshain;Martin Hickey;Jennifer Febbo;Samuel Wann;Robert Philip Eaton(University of New Mexico School of Medicine, Albuquerque, NM, USA)
出处 《World Journal of Cardiovascular Diseases》 2022年第6期320-341,共22页 心血管病(英文)
关键词 Symptomatic Cardiovascular Disease Coronary Artery Calcium Scan Myocardial Infarction Cardiovascular Risk ATHEROSCLEROSIS Risk Equations Symptomatic Cardiovascular Disease Coronary Artery Calcium Scan Myocardial Infarction Cardiovascular Risk Atherosclerosis Risk Equations
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  • 1[1]Endo A.The discovery and development of HMG-CoA reductase inhibitors.J Lipid Res 1992;33:1569-1582
  • 2[2]Brown MS,Goldstein JL.A receptor-mediated pathway for cholesterol homeostasis.Science 1986;232:34-47
  • 3[3]Ong HT.The statin studies:from targeting hypercholesterolaemia to targeting the high-risk patient.QJM 2005;98:599-614
  • 4[4]Illingworth DR,Crouse JR 3rd,Hunninghake DB,Davidson MH,Escobar ID,Stalenhoef AF,Paragh G,Ma PT,Liu M,Melino MR,O'Grady L,Mercuri M,Mitchel YB.A comparison of simvastatin and atorvastatin up to maximal recommended doses in a large multicenter randomized clinical trial.Curr Med Res Opin 2001;17:43-50
  • 5[5]Jones PH,Davidson MH,Stein EA,Bays HE,McKenney JM,Miller E,Cain VA,Blasetto JW.Comparison of the efficacy and safety of rosuvastatin versus atorvastatin,simvastatin,and pravastatin across doses (STELLAR* Trial).Am J Cardiol 2003;92:152-160
  • 6[6]Castelli WP,Garrison RJ,Wilson PW,Abbott RD,Kalousdian S,Kannel WB.Incidence of coronary heart disease and lipoprotein cholesterol levels.The Framingham Study.JAMA 1986;256:2835-2838
  • 7[7]Gordon T,Kannel WB,Castelli WP,Dawber TR.Lipoproteins,cardiovascular disease,and death.The Framingham study.Arch Intern Med 1981;141:1128-1131
  • 8[8]Sudhop T,Lutjohann D,Kodal A,Igel M,Tribble DL,Shah S,Perevozskaya I,von Bergmann K.Inhibition of intestinal cholesterol absorption by ezetimibe in humans.Circulation 2002;106:1943-1948
  • 9[9]Miettinen TA,Puska P,Gylling H,Vanhanen H,Vartiainen E.Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population.N Engl J Med 1995;333:1308-1312
  • 10[10]Maxfield FR,Tabas I.Role of cholesterol and lipid organization in disease.Nature 2005;438:612-621

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