摘要
Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods: Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results: Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion: Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.
Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods: Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results: Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion: Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.
作者
Victoria Delicado-Useros
Esther Navarro-Rodenas
Indalecio-M Sánchez-Onrubia
Carmen Ortega-Martínez
Antonia Alfaro-Espín
Juan-D Pérez-Serra
Francisco García-Alcaraz
Julia Lozano-Serra
Lorena Robles-Fonseca
Teresa Pérez-Domenech
Victoria Delicado-Useros;Esther Navarro-Rodenas;Indalecio-M Sánchez-Onrubia;Carmen Ortega-Martínez;Antonia Alfaro-Espín;Juan-D Pérez-Serra;Francisco García-Alcaraz;Julia Lozano-Serra;Lorena Robles-Fonseca;Teresa Pérez-Domenech(Nursing Faculty Castilla-La Mancha University, Nursing & Society Research Group, Albacete, Spain;Emergency Department, General Hospital, Almansa, Spain;Emergency Department, General Hospital, Albacete, Spain;Nursing Faculty, Nursing & Society Research Group, Universidad de Castilla-La Mancha, Albacete, Spain;Emergency Department, Son Espasses Universitary Hospital, Palma de Mallorca, Spain;Departament of Clinical Microbiology in Albacete General Hospital, Albacete, Spain)
