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Modelling and Simulation of the Spread of HBV Disease with Infectious Latent 被引量:1

Modelling and Simulation of the Spread of HBV Disease with Infectious Latent
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摘要 This paper studies the global behavior of the spread of HBV using a SEIR model with a constant vaccination rate. The infectivity during the incubation period is considered as a second way of transmission. The basic reproduction number R0 is derived as a function of the two contact rates?β1?and β2?. There is a disease free equilibrium point (DFE) of our model. When R0 R0 > 1, there is a unique endemic equilibrium. We proved that the endemic equilibrium was globally asymptotically stable when R0 > 1 and that the disease persisted in the population. These results are original for our model with vaccination and two contact rates. This paper studies the global behavior of the spread of HBV using a SEIR model with a constant vaccination rate. The infectivity during the incubation period is considered as a second way of transmission. The basic reproduction number R0 is derived as a function of the two contact rates?β1?and β2?. There is a disease free equilibrium point (DFE) of our model. When R0 R0 > 1, there is a unique endemic equilibrium. We proved that the endemic equilibrium was globally asymptotically stable when R0 > 1 and that the disease persisted in the population. These results are original for our model with vaccination and two contact rates.
出处 《Applied Mathematics》 2015年第5期745-753,共9页 应用数学(英文)
关键词 HBV Modelling Global Stability Simulation Two Contact Rates Basic REPRODUCTION NUMBER R0 HBV Modelling Global Stability Simulation Two Contact Rates Basic Reproduction Number R0
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