摘要
This study focuses on the development possibilities of radiotracers used in PET in Senegal. This is a literature review that develops the production of 68-Gallium (<sup>68</sup>Ga[Ga]) via a medium to low energy cyclotron. It shows the possibility of producing <sup>68</sup>Ga[Ga] with a simple production reaction using a target of <sup>68</sup>Zn. This reaction provides high production yields, at the end of the bombardment (EOB), reaching up to 80 times the activity of a generator. PET imaging may offer better sensitivity and spatial resolution compared to SPECT which is currently used in Senegal. The acquisition of this type of medium to low energy accelerator in Senegal may constitute an important phase in the development of radiotracers with the objective of installing a PET imaging. However, solutions must be provided to minimize the presence of isotopic impurities.
This study focuses on the development possibilities of radiotracers used in PET in Senegal. This is a literature review that develops the production of 68-Gallium (<sup>68</sup>Ga[Ga]) via a medium to low energy cyclotron. It shows the possibility of producing <sup>68</sup>Ga[Ga] with a simple production reaction using a target of <sup>68</sup>Zn. This reaction provides high production yields, at the end of the bombardment (EOB), reaching up to 80 times the activity of a generator. PET imaging may offer better sensitivity and spatial resolution compared to SPECT which is currently used in Senegal. The acquisition of this type of medium to low energy accelerator in Senegal may constitute an important phase in the development of radiotracers with the objective of installing a PET imaging. However, solutions must be provided to minimize the presence of isotopic impurities.
作者
Papa Mady Sy
Mounibé Diarra
Papa Mady Sy;Mounibé Diarra(Laboratory of Physics and Pharmaceutical Biophysics, Faculty of Medicine, Pharmacy and Odontology, UCAD, Dakar, Senegal)
