摘要
The blood neutrophils to lymphocytes ratio (NLR) reflects the physiological homeostasis between lymphopoiesis and myelopoiesis, and its elevation serves as a harmful sign in many pathologies, partially, late rejection of allograft. The stem and young lymphoid cells have regenerative-trophic properties, which can affect the relevance of NLR, being opposed to immune properties, associated with bulk lymphocytes. In the present article, we have analyzed for the first time the applicability of NLR’s analogs with stem and immature blood cells for monitoring harmful long-term shifting from lymphopoiesis to myelopoiesis in transplant’s recipients received conventional immunosuppressive treatment. In opposition to conventional NLR, the ratio of subpopulation of CD31 cells committed to the liver tissue by alfa-fetoprotein (AFP), seems sensitive enough for such monitoring several years after transplantation of the liver from the dead.
The blood neutrophils to lymphocytes ratio (NLR) reflects the physiological homeostasis between lymphopoiesis and myelopoiesis, and its elevation serves as a harmful sign in many pathologies, partially, late rejection of allograft. The stem and young lymphoid cells have regenerative-trophic properties, which can affect the relevance of NLR, being opposed to immune properties, associated with bulk lymphocytes. In the present article, we have analyzed for the first time the applicability of NLR’s analogs with stem and immature blood cells for monitoring harmful long-term shifting from lymphopoiesis to myelopoiesis in transplant’s recipients received conventional immunosuppressive treatment. In opposition to conventional NLR, the ratio of subpopulation of CD31 cells committed to the liver tissue by alfa-fetoprotein (AFP), seems sensitive enough for such monitoring several years after transplantation of the liver from the dead.
作者
Aleksey N. Shoutko
Olga A. Gerasimova
Aleksey N. Shoutko;Olga A. Gerasimova(Department of Transplantation, Stem Cells of Russian Research Center of Radiology and Surgical Technologies named after A. M. Granov, Saint-Petersburg, Russia)
