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Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia

Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia
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摘要 The aim of this study was to determine whether 9 genetic polymorphisms confered susceptibility to schizophrenia (SCZ). The authors conducted meta-analyses on associations between SCZ and 9 variants of 6 genes including PIK3C3 (432C > T), ABCB1 (C3435T and G2677T), CTLA4 (+49A/G), OLIG2 (rs762178), GAD1 (rs1978340, rs3749034 and rs769395), and GRIN1 (G1001C). A total of 34 case-control studies were involved in our meta-analyses. Our results showed no significant association between all the loci and SCZ. This meta-analysis confirmed a lack of association of SCZ for 9 genetic polymorphisms including GRIN1 G1001C, ABCB1 C3435T and G2677T, CTLA4 + 49A/G, OLIG2 rs762178, GAD1 gene rs1978340, rs3749034 and rs769395, and PIK3C3 432C > T. The aim of this study was to determine whether 9 genetic polymorphisms confered susceptibility to schizophrenia (SCZ). The authors conducted meta-analyses on associations between SCZ and 9 variants of 6 genes including PIK3C3 (432C > T), ABCB1 (C3435T and G2677T), CTLA4 (+49A/G), OLIG2 (rs762178), GAD1 (rs1978340, rs3749034 and rs769395), and GRIN1 (G1001C). A total of 34 case-control studies were involved in our meta-analyses. Our results showed no significant association between all the loci and SCZ. This meta-analysis confirmed a lack of association of SCZ for 9 genetic polymorphisms including GRIN1 G1001C, ABCB1 C3435T and G2677T, CTLA4 + 49A/G, OLIG2 rs762178, GAD1 gene rs1978340, rs3749034 and rs769395, and PIK3C3 432C > T.
作者 Xuting Xu Lingyan Wang Qi Liao Leiting Xu Yi Huang Fuqiang Zhang Jia Cheng Meng Ye Shugui Gao Shiwei Duan
机构地区 Bank of Blood Products Department of Psychiatry Ningbo Addiction Research and Treatment Center The Affiliated Hospital Zhejiang Provincial Key Laboratory of Pathophysiology
出处 《Advances in Bioscience and Biotechnology》 2014年第2期81-88,共8页 生命科学与技术进展（英文）
关键词 SCHIZOPHRENIA META-ANALYSIS SNP Schizophrenia Meta-Analysis SNP
分类号 R73 [医药卫生—肿瘤]
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Advances in Bioscience and Biotechnology
2014年 第2期

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