摘要
In 2019, the coronavirus pandemic broke out as a serious public health issue worldwide. In Côte d’Ivoire, the number of cases of COVID-19 has increased rapidly. The Severe Acute Respiratory Syndrome virus (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) receptors in the respiratory tracts and enters the respiratory and alveolar cells of infected patients. Deficiency of fat-soluble vitamin D<sub>3</sub> is associated with respiratory distress syndrome and pulmonary fibrosis by activation of the renin-angiotensin system. In Côte d’Ivoire, very little research is being done on SARS-CoV-2 and vitamin D. The objective of this study was to assess the vitamin D status of people infected and suffering from COVID-19 in order to contribute to their medical treatment. The study involved 100 adults infected with SARS-CoV-2 (24 women and 76 men). After confirmation of the patient’s SARS-CoV-2 status by RT-PCR, the 25 (OH) vitamin D assay was performed on the Cobas 6000 device and compared to control subjects, the non-COVID-19 positive. A significant decrease in 25-hydroxy vitamin D<sub>3</sub> concentrations (44 ± 1.29 nmole/L) was observed in patients infected with SARS-CoV-2, compared to control (78 ± 0.68 nmole/L) (p < 0.0001). The 25-hydroxy vitamin D<sub>3</sub> deficiency requires vitamin D supplementation in the management of hospitalized patients infected with SARS-CoV-2.
In 2019, the coronavirus pandemic broke out as a serious public health issue worldwide. In Côte d’Ivoire, the number of cases of COVID-19 has increased rapidly. The Severe Acute Respiratory Syndrome virus (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) receptors in the respiratory tracts and enters the respiratory and alveolar cells of infected patients. Deficiency of fat-soluble vitamin D<sub>3</sub> is associated with respiratory distress syndrome and pulmonary fibrosis by activation of the renin-angiotensin system. In Côte d’Ivoire, very little research is being done on SARS-CoV-2 and vitamin D. The objective of this study was to assess the vitamin D status of people infected and suffering from COVID-19 in order to contribute to their medical treatment. The study involved 100 adults infected with SARS-CoV-2 (24 women and 76 men). After confirmation of the patient’s SARS-CoV-2 status by RT-PCR, the 25 (OH) vitamin D assay was performed on the Cobas 6000 device and compared to control subjects, the non-COVID-19 positive. A significant decrease in 25-hydroxy vitamin D<sub>3</sub> concentrations (44 ± 1.29 nmole/L) was observed in patients infected with SARS-CoV-2, compared to control (78 ± 0.68 nmole/L) (p < 0.0001). The 25-hydroxy vitamin D<sub>3</sub> deficiency requires vitamin D supplementation in the management of hospitalized patients infected with SARS-CoV-2.
作者
Lydie Boyvin
Yapi Guillaume Yayé
Gnogbo Alexis Bahi
Aya Jeanne Armande Aké
Kipré Laurent Séri
Daouda Sévédé
Serge Eholié
Mireille Dosso
Allico Joseph Djaman
Lydie Boyvin;Yapi Guillaume Yayé;Gnogbo Alexis Bahi;Aya Jeanne Armande Aké;Kipré Laurent Séri;Daouda Sévédé;Serge Eholié;Mireille Dosso;Allico Joseph Djaman(Department of Fundamental & Medical Biochemistry, Institut Pasteur of Côte d’Ivoire (IPCI), Abidjan, Côte d’Ivoire;Biology and Health Laboratory, University Félix Houphouët-Boygny (UFHB), Abidjan, Côte d’Ivoire;Department of Biochemistry-Microbiology, University of Jean Lorougnon Guédé, Daloa, Côte d’Ivoire;Department of Bacteriology-Virology, Institut Pasteur of Côte d’Ivoire (IPCI), Abidjan, Côte d’Ivoire;Department of Infectious Diseases of the Treichville University Hospital Center, Abidjan, Côte d’Ivoire)
