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Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease

Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease
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摘要 Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form. Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form.
作者 Angelo M. Scanu Diana M. Stafforini Celina Edelstein
机构地区 Department of Medicine Department of Medicine Department of Biochemistry and Molecular Biology Huntsman Cancer Institute
出处 《American Journal of Molecular Biology》 2012年第2期110-112,共3页 美国分子生物学期刊（英文）
关键词 PLASMINOGEN Apolipoprotein(a) Lipoprotein(a) OXIDIZED PHOSPHOLIPIDS OXIDIZED PHOSPHATIDYLCHOLINES Plasminogen Apolipoprotein(a) Lipoprotein(a) Oxidized Phospholipids Oxidized Phosphatidylcholines
分类号 R5 [医药卫生—内科学]
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共引文献12

American Journal of Molecular Biology
2012年 第2期

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