摘要
Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS- PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis (with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF) and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results: No significant difference in ADHD prevalence was observed between subjects with the synapsin III gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but synapsin polymorphisms could be associated with Stroop simple reaction time.
Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS- PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis (with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF) and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results: No significant difference in ADHD prevalence was observed between subjects with the synapsin III gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but synapsin polymorphisms could be associated with Stroop simple reaction time.
作者
Ahmet Buber
Burge Kabukcu Basay
Omer Basay
Onder Ozturk
Huseyin Alacam
Kemal Utku Yazici
Ali Bacanli
Mustafa Ertan Ay
Mehmet Emin Erdal
Hasan Herken
Eyup Sabri Ercan
Ahmet Buber;Burge Kabukcu Basay;Omer Basay;Onder Ozturk;Huseyin Alacam;Kemal Utku Yazici;Ali Bacanli;Mustafa Ertan Ay;Mehmet Emin Erdal;Hasan Herken;Eyup Sabri Ercan(Child and Adolescent Psychiatry Department, Pamukkale University Medical Faculty, Denizli, Turkey;Psychiatry Department, Pamukkale University Medical Faculty, Denizli, Turkey;Child and Adolescent Psychiatry Department, Firat University Medical Faculty, Elazig, Turkey;Child and Adolescent Psychiatry Department, Gaziantep Children Hospital, Gaziantep, Turkey;Medical Biology and Genetics Department, Mersin University Medical Faculty, Mersin, Turkey;Child and Adolescent Psychiatry Department, Ege University Medical Faculty, Izmir, Turkey)
