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Human Amniotic Membrane Promotes Antimicrobial Microenvironment in a Device-Related Infection

Human Amniotic Membrane Promotes Antimicrobial Microenvironment in a Device-Related Infection
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摘要 Hospital inquired post-operative infections are a leading cause of morbidity and mortality in patients receiving left ventricular assist devices. We present the case of a patient who acquired Candida albicans and Staphylococci infections following left ventricular assist device implantation. Use of standard antibiotics caused the infection to worsen, thus an amniotic membrane patch was used as a last-resort treatment. Within 6 weeks of the amniotic membrane patch treatment, the infection resolved, the wound appeared exceptionally clean upon inspection, and granulation tissue was present. After the infection resolved, a successful latissimusdorsi tissue flap procedure was completed and the patient made a full recovery. Hospital inquired post-operative infections are a leading cause of morbidity and mortality in patients receiving left ventricular assist devices. We present the case of a patient who acquired Candida albicans and Staphylococci infections following left ventricular assist device implantation. Use of standard antibiotics caused the infection to worsen, thus an amniotic membrane patch was used as a last-resort treatment. Within 6 weeks of the amniotic membrane patch treatment, the infection resolved, the wound appeared exceptionally clean upon inspection, and granulation tissue was present. After the infection resolved, a successful latissimusdorsi tissue flap procedure was completed and the patient made a full recovery.
作者 Alice S. Ferng Katherine M. Marsh Tia R. Pilikian Alana Connell Courtney Hemphill Samata Paidy Ray Runyan John Konhilas Zain Khalpey Alice S. Ferng;Katherine M. Marsh;Tia R. Pilikian;Alana Connell;Courtney Hemphill;Samata Paidy;Ray Runyan;John Konhilas;Zain Khalpey(Department of Surgery, Division of Cardiothoracic Surgery, University of Arizona, Tucson, AZ, USA;College of Medicine-Tucson, University of Arizona, Tucson, AZ, USA;Department of Physiological Sciences, University of Arizona, Tucson, AZ, USA;Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA;Banner-University Medical Center, Tucson, AZ, USA;Amnio Technology LLC, Phoenix, AZ, USA;Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA;Department of Anesthesia, University of Arizona, Tucson, AZ, USA;Department of Medical Imaging, University of Arizona, Tucson, AZ, USA)
出处 《Journal of Biomedical Science and Engineering》 2016年第2期122-126,共5页 生物医学工程(英文)
关键词 ANTIMICROBIAL Amniotic Membrane Ventricular Assist Device Antimicrobial Amniotic Membrane Ventricular Assist Device
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