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Computational Molecular Analysis of the Sequences of BMP15 Gene of Ruminants and Non-Ruminants

Computational Molecular Analysis of the Sequences of BMP15 Gene of Ruminants and Non-Ruminants
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摘要 Bone morphogenetic protein 15 (BMP15) is a member of the transforming growth factor β (TGFβ) super family that is expressed by oocytes and plays key roles in granulosa cell development and fertility in animal. This study investigated the molecular genetic variation of BMP15 gene of some selected mammalian species with a view to providing relevant genetic information for breeding and selection programmes in the studied species using computational methods. A total of thirty seven (37) BMP15 nucleotide sequences comprising goats (18), sheep (6), cattle (6), swine (4) and chicken (3) were retrieved from the GenBank. Sequence alignment, translation and comparison of the BMP15 gene of the various species were done with ClustalW. High degree of polymorphism of BMP15 gene was observed among the studied species. The significant value (P bovidae family (goat, sheep and cattle). The present information could guide future efforts involving selection of markers of fecundity to improve genetically livestock species in Nigeria. Bone morphogenetic protein 15 (BMP15) is a member of the transforming growth factor β (TGFβ) super family that is expressed by oocytes and plays key roles in granulosa cell development and fertility in animal. This study investigated the molecular genetic variation of BMP15 gene of some selected mammalian species with a view to providing relevant genetic information for breeding and selection programmes in the studied species using computational methods. A total of thirty seven (37) BMP15 nucleotide sequences comprising goats (18), sheep (6), cattle (6), swine (4) and chicken (3) were retrieved from the GenBank. Sequence alignment, translation and comparison of the BMP15 gene of the various species were done with ClustalW. High degree of polymorphism of BMP15 gene was observed among the studied species. The significant value (P bovidae family (goat, sheep and cattle). The present information could guide future efforts involving selection of markers of fecundity to improve genetically livestock species in Nigeria.
作者 Bwaseh S. Bibinu Abdulmojeed Yakubu Steven B. Ugbo Ndu I. Dim Bwaseh S. Bibinu;Abdulmojeed Yakubu;Steven B. Ugbo;Ndu I. Dim(Department of Animal Breeding and Physiology, University of Agriculture Makurdi, Makurdi, Nigeria;Department of Animal Science, Faculty of Agriculture, Nasarawa State University, Keffi, Shabu-Lafia Campus, Lafia, Nigeria)
出处 《Open Journal of Genetics》 2016年第2期39-50,共12页 遗传学期刊(英文)
关键词 BMP15 SEQUENCES SNPs PHYLOGENY RUMINANTS Non-Ruminants BMP15 Sequences SNPs Phylogeny Ruminants Non-Ruminants
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