摘要
<span style="font-family:""><span style="font-family:Verdana;">T</span><span><span style="font-family:Verdana;">he present study reports the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> anti-Mycobacterial Activity of a Phytomedicine </span></span></span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">MATHESIA</span><span style="font-family:Verdana;">”</span><span style="font-family:""><span style="font-family:Verdana;"> on </span><i><span style="font-family:Verdana;">Mycobacterium ulcerans</span></i><span style="font-family:Verdana;">. It also explores the influence of ethanolamine (alkali agent) on the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> activity of some antibiotics (Isoniazid, Rifampicin, Ethambutol) used in the treatment of Buruli ulcers in DR Congo. Experiments were conducted on adult white Wistar rats of both sex</span></span><span style="font-family:Verdana;">es</span><span style="font-family:Verdana;"> with the weights comprising between 110</span><span style="font-family:Verdana;"> - </span><span style="font-family:Verdana;">165</span><span style="font-family:""> </span><span style="font-family:Verdana;">g.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The result obtained have show</span><span style="font-family:Verdana;">n</span><span style="font-family:""><span style="font-family:Verdana;"> that the phytomedicine MATHESIA (pH 10) has a good </span><i><span style="font-family:Verdana;">in vivo </span></i><span style="font-family:Verdana;">activity on </span><i><span style="font-family:Verdana;">M. ulcerans</span></i><span style="font-family:Verdana;"> and the duration for wounds healing and total cicatrization was 6 days;whereas this duration was 10, 12, 14, and 16 days respectively</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">for Rifampicin (IV, pH 10), Kibadi</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s solution (X, pH 10), Ethambutol (VIII, pH 10) and Isoniazid (VI, pH 10).</span><span style="font-family:""> </span><span style="font-family:Verdana;">The result also showed that the use of the ethanolamine as alkali compound</span><span style="font-family:Verdana;">ed</span><span style="font-family:Verdana;"> in the treatment of wounds due to Buruli ulcer along with other antibiotics reduced considerably the duration of complete healing comparatively to their solutions at pH bellow or equal to 7.
<span style="font-family:""><span style="font-family:Verdana;">T</span><span><span style="font-family:Verdana;">he present study reports the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> anti-Mycobacterial Activity of a Phytomedicine </span></span></span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">MATHESIA</span><span style="font-family:Verdana;">”</span><span style="font-family:""><span style="font-family:Verdana;"> on </span><i><span style="font-family:Verdana;">Mycobacterium ulcerans</span></i><span style="font-family:Verdana;">. It also explores the influence of ethanolamine (alkali agent) on the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> activity of some antibiotics (Isoniazid, Rifampicin, Ethambutol) used in the treatment of Buruli ulcers in DR Congo. Experiments were conducted on adult white Wistar rats of both sex</span></span><span style="font-family:Verdana;">es</span><span style="font-family:Verdana;"> with the weights comprising between 110</span><span style="font-family:Verdana;"> - </span><span style="font-family:Verdana;">165</span><span style="font-family:""> </span><span style="font-family:Verdana;">g.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The result obtained have show</span><span style="font-family:Verdana;">n</span><span style="font-family:""><span style="font-family:Verdana;"> that the phytomedicine MATHESIA (pH 10) has a good </span><i><span style="font-family:Verdana;">in vivo </span></i><span style="font-family:Verdana;">activity on </span><i><span style="font-family:Verdana;">M. ulcerans</span></i><span style="font-family:Verdana;"> and the duration for wounds healing and total cicatrization was 6 days;whereas this duration was 10, 12, 14, and 16 days respectively</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">for Rifampicin (IV, pH 10), Kibadi</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s solution (X, pH 10), Ethambutol (VIII, pH 10) and Isoniazid (VI, pH 10).</span><span style="font-family:""> </span><span style="font-family:Verdana;">The result also showed that the use of the ethanolamine as alkali compound</span><span style="font-family:Verdana;">ed</span><span style="font-family:Verdana;"> in the treatment of wounds due to Buruli ulcer along with other antibiotics reduced considerably the duration of complete healing comparatively to their solutions at pH bellow or equal to 7.
作者
L. H. Nkasa
K. J. Kadinekene
O. Kiabanzawoko
B. Tchey
S. Kimbonza
M. O. Lunguya
S. S. Karhemere Bin
M. C. Mulenga
T. J. J. Muyembe
S. J. Kayembe
K. M. Taba
L. H. Nkasa;K. J. Kadinekene;O. Kiabanzawoko;B. Tchey;S. Kimbonza;M. O. Lunguya;S. S. Karhemere Bin;M. C. Mulenga;T. J. J. Muyembe;S. J. Kayembe;K. M. Taba(Department of Chemistry, Faculty of Sciences, University of Kinshasa, Kinshasa, DR Congo;Department of Surgery, Faculty of Medicine, University of Kinshasa, Kinshasa, DR Congo;BU Project of the Evangelic Medical Institute of Kimpese, Kongo Central, DR Congo;National Program for Tuberculosis Control, Kinshasa, DR Congo;National Institute of Biomedical Research, Kinshasa, DR Congo;Department of Medical Biology, Faculty of Medicine, University of Kinshasa, Kinshasa, DR Congo)
