摘要
Buoyed by the extensive research on the wide-range biological activities of aminophosphonates, a novel class of aminated (cyclopropylmethyl)phosphor-nates compounds was synthesized from diethyl ((1-(3-chloropropyl)cyclopropyl)methyl)phosphonate and various amines in the presence of Hunig’s base. Upon biological activity screening these compounds demonstrated encouraging anti-pancreatic cancer properties at low micromolar concentrations.
Buoyed by the extensive research on the wide-range biological activities of aminophosphonates, a novel class of aminated (cyclopropylmethyl)phosphor-nates compounds was synthesized from diethyl ((1-(3-chloropropyl)cyclopropyl)methyl)phosphonate and various amines in the presence of Hunig’s base. Upon biological activity screening these compounds demonstrated encouraging anti-pancreatic cancer properties at low micromolar concentrations.
作者
Abed Al Aziz Al Quntar
Ibrahim Abasy
Hasan Dweik
Michel Maffei
Valery M. Dembitsky
Abed Al Aziz Al Quntar;Ibrahim Abasy;Hasan Dweik;Michel Maffei;Valery M. Dembitsky(Department of Chemistry and Chemical Technology, Faculty of Science and Technology, Al-Quds University, Jerusalem, Palestine;Department of Microbiology and Immunology, Al-Quds University, Jerusalem, Palestine;Institut des Sciences Moleculaires de Marseille (iSm2), Aix-Marseille University, CNRS, Centrale Marseille, Marseille, France;Bio-Geo-Chem Laboratories, Ltd., Aliso Viejo, USA)
