摘要
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m<sup>2</sup>/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO<sub>2</sub> materials were proved to be a suitable system for controlled release of paracetamol.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m<sup>2</sup>/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO<sub>2</sub> materials were proved to be a suitable system for controlled release of paracetamol.
作者
Tessy López
Mayra Álvarez
Paola Ramírez
Gustavo Jardón
Miriam López
Guadalupe Rodriguez
Itzel Ortiz
Octavio Novaro
Tessy López;Mayra Álvarez;Paola Ramírez;Gustavo Jardón;Miriam López;Guadalupe Rodriguez;Itzel Ortiz;Octavio Novaro(Laboratorio de Nanotecnología y Nanomedicina, Universidad Autónoma Metropolitana-Xochimilco, México D.F., México;Laboratorio de Nanotecnología, Instituto Nacional de Neurología y Neurocirugía “MVS”, México D.F., México;Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, USA;Instituto de Física, Universidad Nacional Autónoma de México, Circuito de la Investigación s/n, México D.F., México)
