摘要
The objective of this research was to elucidate the biological effect of novel compounds derived from natural product of syringaldehyde through novel semi-synthetic method in order to investigate the physicochemical properties and biological activities by using DPPH and FRAP techniques and its antibacterial activities against Klebsiella spp., Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. Moreover, to examine its ability against breast cancer cell line (MCF-7). The results showed that the syringaldehyde hydrazonate copper complexes possessed the covalent bonds with square-planar structure. In terms of antioxidant DPPH activities, it was found that syringaldehyde hydrazone possessed high potency against DPPH free radicals, with respect to syringaldehyde hydrazonate copper complexes. On the other hand, all compounds possessed low reducing properties for changing Fe<sup>3+</sup> to Fe<sup>2+</sup> in FRAP technique. For antibacterial activities revealed that the ligand L1 and L5 possessed high effect on Pseudomonas aeruginosa, but for all copper complexes possessed high potent antibacterial susceptibility to four bacteria with concentration dependence. For anti-breast cancer cell line (MCF-7), it was found that all compounds possessed high potent anticancer susceptibility with low IC<sub>50</sub>, especially, compound exhibit highly potency effective is C5 (IC<sub>50</sub> 9.75 μM). The tendency of anticancer effect from high to low was C5 > C2 > C1 > C4 > C3. Therefore, all synthetic compounds obtained from the present research possibly develop as the antibacterial drugs and the drugs for curing the diseases caused by free radicals, including breast cancer in metastatic phase. The most important feature of these drugs was the high specificity to the target and harmless to the normal cells.
The objective of this research was to elucidate the biological effect of novel compounds derived from natural product of syringaldehyde through novel semi-synthetic method in order to investigate the physicochemical properties and biological activities by using DPPH and FRAP techniques and its antibacterial activities against Klebsiella spp., Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. Moreover, to examine its ability against breast cancer cell line (MCF-7). The results showed that the syringaldehyde hydrazonate copper complexes possessed the covalent bonds with square-planar structure. In terms of antioxidant DPPH activities, it was found that syringaldehyde hydrazone possessed high potency against DPPH free radicals, with respect to syringaldehyde hydrazonate copper complexes. On the other hand, all compounds possessed low reducing properties for changing Fe<sup>3+</sup> to Fe<sup>2+</sup> in FRAP technique. For antibacterial activities revealed that the ligand L1 and L5 possessed high effect on Pseudomonas aeruginosa, but for all copper complexes possessed high potent antibacterial susceptibility to four bacteria with concentration dependence. For anti-breast cancer cell line (MCF-7), it was found that all compounds possessed high potent anticancer susceptibility with low IC<sub>50</sub>, especially, compound exhibit highly potency effective is C5 (IC<sub>50</sub> 9.75 μM). The tendency of anticancer effect from high to low was C5 > C2 > C1 > C4 > C3. Therefore, all synthetic compounds obtained from the present research possibly develop as the antibacterial drugs and the drugs for curing the diseases caused by free radicals, including breast cancer in metastatic phase. The most important feature of these drugs was the high specificity to the target and harmless to the normal cells.
作者
Sommai Patitungkho
Kingkaew Patitungkho
Sommai Patitungkho;Kingkaew Patitungkho(Department of Chemistry, Faculty of Science, Buriram Rajabhat University, Buriram, Thailand;Department of Library & Information Science, Buriram Rajabhat University, Buriram, Thailand)
