自噬在自身免疫性疾病中的研究进展

Molecular mechanism of autophagy in autoimmune disease

类风湿性关节炎和系统性红斑狼疮是最主要和典型的自身免疫性疾病，但其确切机制尚未完全清楚。自噬是高度保守的依赖于溶酶体降解自身胞内大分子和细胞器的分解代谢过程。自噬现象广泛存在于各种组织中并参与维持细胞存活、分化及内环境稳定，近年来受到广泛关注并成为研究热点之一。该文就自噬在类风湿性关节炎和系统性红斑狼疮中的研究进展作一综述。

Rheumatoid arthritis ( RA ) and systemic lupus erythematosus ( SLE ) are the most important and typical autoimmune diseases,however their exact mechanisms has not yet been clear. Autohpagy,a highly conserved process,depends on catabolism of lysosomal degradation of macromolecules or organelles within the cell itself. Autophagy exists widely in various tissues and is involved in maintaining survival and differentiation of cell or the stablility of internal environment. Recently,autophagy has gained wider attention and been one of the hot points of relative reserches. In this review we′ll sum up the development of autophagy in RA and SLE.