膀胱输尿管反流相关基因的研究进展

Progress in genetics of vesicoureteral reflux

膀胱输尿管反流是先天性肾脏和尿路畸形中最常见的一种类型，主要与输尿管膀胱连接部发育异常有关。除非伴有尿路感染症状，或是综合征的一部分，多数患儿临床表现不明显。膀胱输尿管反流的确切病因还不清楚，可能是由基因异常引起，也可能受环境因素影响。膀胱输尿管反流患者后代和同胞间的患病率明显高于正常儿童，提示了基因筛查的必要性。该文将对膀胱输尿管反流相关基因的研究进展及相互作用作一综述。

Vesicoureteral reflux,a most common congenital anomaly of the kidney and urinary tract,is associated with the malformation of ureterovesical junction. It does not cause any specific symptoms or signs un-less it is part of a syndrome or complicated by urinary tract infection. The exact cause is not clear,and genes or environmental factors may result in vesicoureteral reflux. The prevalence of siblings and offspring of reflux pa-tients are higher than normal control groups,so the genetic screening is necessary. This article will review the ge-netics of vesicoureteral reflux and possible interactions.