新生儿高胆红素血症对机体的损伤

Multiple organs injury by neonatal hyperbilirubinemia

新生儿高胆红素血症是新生儿住院的主要原因之一,是常见于新生儿早期的以皮肤巩膜黄染为主要表现的病症.患儿血清总胆红素及未结合胆红素水平大幅度升高,如不及时干预可能对新生儿脑功能、肾功能、听力及心功能产生损伤,严重者可致死亡.研究证实,高胆红素血症对新生儿的脑神经、听力、肾脏及心脏均可造成损伤,且靶器官的受损程度与血中胆红素水平呈正相关.该文就高胆红素血症对新生儿的不良影响作一综述.

Neonatal hyperbilirubinemia is one of the major causes of neonatal hospitalization,which is common in the early stage of the newborn and is characterized by skin and sclera yellow staining.The levels of serum total bilirubin and unconjugated bilirubin increased greatly in children,which may damage the brain function,kidney function,hearing and heart function of the newborn,even cause death.Research has found that hyperbilirubinemia can damage the brain nerve,hearing,kidney and heart of the newborn.The damage degree of target organs is positively related to serum bilirubin level.This article reviews the adverse effects of hyperbilirubinemia on newborns.