肺干细胞疗法:可能修复受损的肺组织

Lung stem cell-based therapy:a possible way to repair the injuried lung

近年来,肺干细胞以其极具前景的特征,包括分化为不同细胞系以及再生能力,激起人们对干细胞治疗终末肺疾病的研究热潮.与其他干细胞类似,现已证明肺干细胞具有分化为其他细胞系的能力,如内皮细胞、上皮细胞和分泌细胞,而这些细胞可以重建肺结构从而促进肺再生.该文综述了世界范围内关于肺干细胞疗法研究的一些观点.目前肺动脉高压导致的终末肺疾病还没有广泛认可的常规治疗方案,但现在理论实验和临床的研究试验为干细胞疗法奠定基础.

Recently,the promising features of lung stem cells,including ability to differentiate into di-verse cell lineages and their regenerative properties,have aroused researchers′ attention,which offers intriguing perspectives on cell-based therapies for end stage lung disease. Associated with various stem cell phenotypes, lung stem cell has been proved to differentiate into cell lineages, such as endothelial, epithelial cell and secret cells,which reconstitute the injured lung then lead to lung regeneration. In the present paper,a comprehensive re-view of stem cell-based clinical trials conducted worldwide that scrutinizes biological properties of lung stem cells and highlights lung stem cell therapeutic effects is elaborated. To date,there is no regulatory approved cell treatment for end stage lung disease,but research and clinical studies offer the hope for successful cell therapy in the next decades.