摘要
OGG1基因是一种广泛存在于真核细胞中的管家基因,可以通过碱基切除修复途径,识别和切除DNA双链中的氧化损伤产物8-oxoG,对DNA进行修复,防止8-oxoG的致突变作用.hOGG1在1996年被成功克隆后,越来越受到人们的重视,现发现OGG1基因在肿瘤发生、衰老及退行性疾病、心肌病以及过敏性疾病等的发生发展中发挥了重要作用.通过深入研究OGG1基因的表达及其调控机制有助于探索治疗这些疾病的新方法.
OGG1 gene is widely expressed in eukaryotic cells as a housekeeping gene,which can identi-fy 8-oxoG,oxidative damage product,and remove it via the base excision repair pathway to repair DNA and pro-tect it from mutation. Increasing attention is paid to investigate the OGG1 gene,which is found to play an impor-tant role in tumorigenesis,aging,degenetative diseases,cardiomyopathy,and allergic diseases. Insight of the ex-pression of OGG1 and its regulatory mechanism can bring us a new way to treat these diseases.
出处
《国际儿科学杂志》
2017年第9期615-618,共5页
International Journal of Pediatrics
基金
国家自然科学基金(81571479)National Natural Science Foundation of China
