儿童肺炎支原体携带及其PCR检测

Carriage and the detection of PCR with Mycoplasma pneumoniae in children

肺炎支原体是儿童呼吸道感染常见的病原体之一.肺炎支原体感染症状轻重不一,有一定的自限性,少数可引起严重的肺外并发症.因肺炎支原体感染的症状和影像学无特异性,需借助血清学、分子生物学方法,如PCR进行早期诊断,以指导正确的治疗,减少耐药发生.另外最近研究显示肺炎支原体可在健康儿童上呼吸道携带,目前临床很难区别携带与感染,无症状携带者既可能是近期感染的结果,也可能是感染后病原的持续存在.

Mycoplasma pneumonia(MP)is a common cause of respiratory tract infections in children. The symptoms of MP infection range from mild to severe,which is often self-limiting.A few cases can develop to severe extrapulmonary complications.Because the symptoms and imagings of MP infection are not specific,so it may by means of diagnostic tests such as serology or PCR to guide the accurate therapy and to reduce the oc-currence of drug-resistance.In addition,recent studies indicate that MP can be carriage in the upper respiratory tract among healthy children,but clinically it is discriminate between MP infection and carriage.The asympto-matic carriage of MP could be the results of recent infection or the pathogenic persistence after infections.