PAPP-A2基因与胎儿疾病相关性研究进展

Updates on the relationship between PAPP-A2 and fetus disease

妊娠相关血浆蛋白-A2(Pregnancy-associated plasma protein-A2,PAPP-A2)是一种金属蛋白酶,表达于多种组织和细胞中,尤其在孕妇血清、胎盘中呈高表达.PAPP-A2在胚胎生长发育中起重要作用,异常的PAPP-A2水平与先兆子痫、唐氏综合征、发育性髋关节发育不良等多种疾病存在相关性,但具体机制仍不清楚.该文就PAPP-A2的结构、功能,及与胎儿疾病相关性的研究进展进行综述.

Pregnancy-associated plasma protein-A2(PAPP-A2)is a metalloproteinase,which expresses in many tissues and cells,especially in maternal serum and placenta.PAPP-A2 plays an important role in the em-bryonic growth and development. Abnormal PAPP-A2 levels are associated with pre-eclampsia,Down's syn-drome,developmental dysplasia of the hip and other diseases,but the specific mechanism is still unclear.The mo-lecular structure and function of PAPP-A2,the research advances in the relationship between PAPP-A2 and fetus disease are reviewed in this paper.