摘要
NLRP12(NOD-like receptors family pyrin domain containing 12)是固有免疫系统模式识别受体NOD样受体(NOD-like receptors,NLR)家族的主要成员之一,是胞浆内抵御外来病原体入侵的重要蛋白.在某些情况下,NILRP12能被激活并与下游效应蛋白组装成炎症小体,参与病原清除;另一方面,NL-RP12是NLR家族中少有的具有抗炎作用的分子.该文将对NLRP12的结构与组织分布、功能及其在疾病发生发展中的作用进行综述.
NLRP12 is a member of the NOD-like receptors family in innate immune system,and plays an important role on resistance to intracellular pathogens.Once being activated,NLRP12 could recruit and combine with its downstream effector proteins into inflammasome,thus involving in pathogen clearance.Meanwhile,NLRP12 is one of the several anti-inflammatory molecules in the NOD-like receptors family.In this review,its structure,tissue distribution,function and association with diseases were discussed.
出处
《国际儿科学杂志》
2018年第1期13-16,共4页
International Journal of Pediatrics
关键词
NLRP12
炎症小体
功能
NOD-like receptors family pyrin domain containing 12
Inflammasome
Function
